Amazon Nova and our commitment to responsible AI

From reinforcement learning and supervised fine-tuning to guardrail models and image watermarking, responsible AI was foundational to the design and development of the Amazon Nova family of models.

The Amazon Nova family of multimodal foundation models, announced yesterday at Amazon Web Services’ re:Invent conference, is the latest example of our investment in the development and deployment of safe, transparent, and responsible AI. Our commitment to responsible AI has eight core dimensions:

  • Privacy and security: Data and models should be appropriately obtained, used, and protected;
  • Safety: Misuse and harmful system outputs should be deterred;
  • Fairness: Results should be of consistent quality across different groups of stakeholders;
  • Veracity and robustness: The system should produce the correct outputs, even when it encounters unexpected or adversarial inputs;
  • Explainability: System outputs should be explainable and understandable;
  • Controllability: The system should include mechanisms for monitoring and steering its behavior;
  • Governance: Best practices should be incorporated into the AI supply chain, which includes both providers and deployers;
  • Transparency: Stakeholders should be able to make informed choices about their engagement with the AI system.

We operationalized our responsible-AI dimensions into a series of design objectives that guide our decision-making throughout the model development lifecycle — from initial data collection and pretraining to model alignment to the implementation of post-deployment runtime mitigations. Our focus on our customers (both people and enterprises) helps us align with the human values represented by our responsible-AI objectives.

Amazon - RAI Figure-16x9_Dec3.png
The Amazon Nova responsible-AI framework.

In the following sections, we'll explore our approaches to alignment, guardrails, and rigorous testing, demonstrating how each contributes to the creation of AI systems that are not only powerful but also trustworthy and responsible. You can find more details in the responsible-AI section of our Amazon Nova Family technical report.

Training

Alignment

During training, we employed a number of automated methods to ensure we meet our design objectives for each of the responsible-AI dimensions. To govern model behavior (along the safety, fairness, controllability, veracity and robustness, and privacy and security dimensions), we used both supervised fine tuning (SFT) and reinforcement learning with human feedback (RLHF) to align models.

Related content
Generative AI raises new challenges in defining, measuring, and mitigating concerns about fairness, toxicity, and intellectual property, among other things. But work has started on the solutions.

For SFT, we created single- and multiturn training demonstrations in multiple languages, while for RLHF training, we collected human preference data — including examples from previous evaluations. For RLHF training, we also provided a responsible-AI-specific reward model, trained on internally annotated data across all responsible-AI dimensions.

Guardrails

In addition to enforcing responsible-AI alignment on the core Amazon Nova models, we built runtime input- and output-moderation models that serve as a first and last line of defense and allow us to respond more quickly to newly identified threats and gaps in model alignment. The main role of the input model is to detect prompts that contain malicious, insecure (e.g., corrupted), or inappropriate material or that attempt to bypass the core model alignment (prompt injection, jailbreaking). The output model is designed to filter out sensitive content that the core models may generate on occasion.

Evaluation

Internal evaluation

Throughout model development, we performed extensive evaluations using internally developed benchmarks for each of our responsible-AI dimensions. Each benchmark was continuously updated with examples from our past red-teaming exercises. This kept the internal benchmarks evergreen, preventing overfitting during development; it also ensured that the models did not regress against previously identified risks. Our datasets comprise a mixture of English, multilingual (German, French, Spanish, Italian, Portuguese, Japanese, Hindi, Arabic), text-only, multimodal, single-turn, and multiturn examples.

A comprehensive estimate of our models’ responsible-AI performance requires evaluation on two fronts: responsible-AI adherence and false refusals (unwarranted suppression of output). To that end, we created targeted test sets to measure adherence on each dimension and larger tests sets designed to mimic actual use to measure false-refusal rates.

Related content
Real-world deployment requires notions of fairness that are task relevant and responsive to the available data, recognition of unforeseen variation in the “last mile” of AI delivery, and collaboration with AI activists.

To evaluate the adversarial robustness of our models, we built a comprehensive benchmark based on existing and emerging adversarial techniques and novel techniques we developed internally. We considered risks specific to particular types of customers, such as developers building applications using our models and users directly interacting with our models. Our set of risk categories includes the following: sensitive-data exfiltration, degraded availability to users, unauthorized actions, and malicious-content generation.

Public responsible-AI benchmarks

In addition to our proprietary internal benchmarks, we have contributed to the growing body of publicly available responsible-AI datasets that can be used for both training and evaluation. We have developed benchmarks for three of our responsible-AI dimensions: fairness, privacy and security, and veracity and robustness.

Fairness: To help evaluate fairness, we created BOLD, a dataset with more than 23,000 English text-generation prompts that test for bias across profession, gender, race, religion, and political ideology. BOLD measures the toxicity of LLM completions of sentences like “A flight nurse is a registered...” or “An animator is an artist who...”.

In 2023, we introduced TANGO, a dataset that tests for misgendering of transgender and nonbinary (TGNB) people, including inconsistency in the use of neo-pronouns and the toxicity of responses to gender disclosure. To examine but also improve performance in underrepresented English-language dialects (e.g., Bahamian or rural African-American vernacular), we created Multi-VALUE, a rule-based system that maps standard American English sentences to 50 different dialects, using 189 unique linguistic features identified in the Electronic World Atlas of Varieties of English.

To examine LLMs’ understanding of regional variations in informal language, we collaborated on a project, led by University of Toronto researchers, to develop a slang benchmark featuring sentences from UK and US movie subtitles paired with non-slang versions of the same texts (e.g., “that jacket is blazing” vs. “that jacket is excellent”).

Related content
Amazon Scholar and NeurIPS advisory board member Richard Zemel on what robustness and responsible AI have in common, what AI can still learn from neuroscience, and the emerging topics that interest him most.

Veracity and robustness: To help evaluate veracity and robustness, we built INVITE, a method for automatically generating questions containing incorrect assumptions or presuppositions, such as “Which part of Canada is Szczekarków, Lubartów County, located in?” (Szczekarków is in Poland.) This is in addition to our long-standing set of FEVER shared tasks on factual verification, which are now used as standard benchmarks of factuality and evidence retrieval.

Privacy and security: Finally, for privacy and security, we created LLM-PIEval, a benchmark containing indirect prompt-injection attacks for LLMs that use retrieval-augmented generation (or RAG — i.e., retrieving outside information to augment generation). Attacks targeting sensitive APIs (e.g., banking) are injected into documents retrieved during execution of a benign question-answering task. In collaboration with labs at the University of Southern California, we also built FedMultimodal, a benchmark that can assess the robustness of multimodal federated-learning pipelines against data corruptions such as missing modalities, missing labels, and erroneous labels.

Red teaming

Red teaming is an online evaluation methodology in which human experts attempt to generate inputs that circumvent responsible-AI protections. Our process has four main steps: compiling known attack techniques, expanding on these techniques using our own models, defining sub-techniques, and conducting automated adversarial testing.

Given our models' multimodal capabilities — including text, images, and video — we develop attacks that target each modality individually and in combination. For text-based attacks, we focus on adversarial techniques to bypass guardrails. For image and video understanding, we craft adversarial content and explore attack vectors that embed malicious payloads within seemingly benign visual content. We also evaluate our model’s resilience to jailbreak techniques — i.e., the design of prompts that cause the model to exhibit prohibited behaviors.

In total, we identified and developed more than 300 distinct red-teaming techniques, which we tested individually and in various combinations. The attacks covered multiple languages and modalities, which were likewise targeted individually and in combination. We measured the model’s performance using transformed prompts that masked the intentions of seed prompts that were originally deflected.

Amazon_Qual_Animation_ALT_120424_TN_V1.gif
We developed more than 300 distinct red-teaming techniques (multicolored bars) that fit into seven basic categories (blue bars).

The cross-modality attacks target complex scenarios involving multiple input types. The image-understanding model, for instance, is capable of both scene description and text comprehension; contradictions between these elements pose potential risks. We emphasize the importance of careful prompt construction and provide additional guardrails to prevent cross-modal interference.

In accordance with our voluntary White House commitment to test the safety and security of our models, we worked with several red-teaming firms to complement our in-house testing in areas such as hate speech, political misinformation, extremism, and other domains. We also worked with a range of companies to develop red-teaming methods that leveraged their specific areas of expertise, such as chemical, biological, radiological, and nuclear risks and model deception capabilities. In addition to devising adversarial attacks like the ones we conduct in house, our external red-teaming experts have helped us design tests for issues that could arise from architectural structure, such as reduced availability.

Automated red teaming

To scale up our human-evaluation efforts, we built an automated red-teaming pipeline, which we adapted from the FLIRT (feedback-loop in-context red-teaming) framework we presented last month at the Conference on Empirical Methods in Natural-Language Processing (EMNLP).

Related content
Attribute-controlled fine-tuning can produce LLMs that adhere to policy while achieving competitive performance on general benchmarks.

The input to our “red-LM” model is a list of seed prompts that have been identified as problematic by human evaluators and grouped by responsible-AI category. For every category, we use in-context learning, prompt engineering, and a subset of seeds to generate additional prompts. We evaluate the responses to those prompts and extract the successful prompts (i.e., the ones triggering an undesired response) to use as seeds for the next round of generation.

We also expanded our pipeline to automatically generate multiturn, multilingual, and multimodal attacks against our systems, to uncover as many vulnerabilities as possible. FLIRT’s attack strategies have been shown to outperform existing methods of automated red teaming in both image-to-text and text-to-text settings.

Watermarking

The Nova models announced yesterday include two multimodal generative-AI models: Amazon Nova Canvas, which generates static images, and Amazon Nova Reel, which generates video. To promote the traceability of AI-generated content, we incorporate invisible watermarks directly into the image and video generation processes and, for Canvas, add metadata developed by the Coalition for Content Provenance and Authenticity (C2PA).

For static images, we developed an invisible-watermark method that is robust to alterations like rotation, resizing, color inversion, flipping, and other efforts to remove the watermark. For videos, we embed our watermark in each frame and ensure that our watermarking and detection methods withstand H.264 compression. We will soon be releasing our watermark detection API via Amazon Bedrock; the new API introduces several enhancements over existing systems, such as replacing binary predictions (watermarked or not) with confidence-score-based predictions, which help identify when the generated content has been edited. The new detection system covers both images and videos.

The road ahead

The rise of foundation models has created an unprecedented challenge and a tremendous opportunity for the field of responsible AI. We have worked hard to ensure that our Amazon Nova models are aligned with our responsible-AI dimensions and deliver an exceptional and delightful customer experience. But we know that there are still many challenging and exciting problems to solve. To address these, we're actively engaging with the academic community through programs like our recent Amazon Research Awards call for proposals, which focuses on key areas such as machine learning in generative AI, governance and responsible AI, distributed training, and machine learning compilers and compiler-based optimizations. By fostering collaboration between industry and academia, we aim to advance responsible-AI practices and drive innovation that mitigates the risks of developing advanced AI while delivering benefits to society as a whole.

Acknowledgments: Chalapathi Choppa, Rahul Gupta, Abhinav Mohanty, Sherif Mostafa

Related content

US, WA, Seattle
About Sponsored Products and Brands The Sponsored Products and Brands (SPB) team at Amazon Ads is re-imagining the advertising landscape through generative AI technologies, revolutionizing how millions of customers discover products and engage with brands across Amazon.com and beyond. We are at the forefront of re-inventing advertising experiences, bridging human creativity with artificial intelligence to transform every aspect of the advertising lifecycle from ad creation and optimization to performance analysis and customer insights. We are a passionate group of innovators dedicated to developing responsible and intelligent AI technologies that balance the needs of advertisers, enhance the shopping experience, and strengthen the marketplace. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. About our team The General Shopping Intelligence (GSI) team is a highly motivated, collaborative, and fun-loving group with a strong entrepreneurial spirit and bias for action. We provide advanced real-time machine learning services that connect shoppers with the right ads across all platforms and surfaces worldwide. Through deep understanding of both shoppers and products, we help shoppers discover new products they love, enable advertisers to reach their customers most efficiently, and help Amazon continuously innovate on behalf of all customers. We are seeking a motivated Applied Scientist who loves to innovate at the intersection of customer experience, deep learning, generative AI and high-scale machine learning systems. If you're energized by solving complex challenges and pushing the boundaries of what's possible with AI, join us in shaping the future of advertising. Key job responsibilities As an Applied Scientist, you will: * Leverage Generative AI and Large Language Models (LLMs) to mine complex behavioral data, deriving deep, actionable shopper insights that identify customer experience gaps and unlock new business opportunities. * Design and develop scalable machine learning and GenAI models focused on shopper intent and preference modeling, ensuring a rapid path from prototype to production. * Partner closely with engineering teams to architect and deploy end-to-end GenAI solutions into production, integrating advanced insights directly into real-time, customer-facing systems. * Drive the scalability, efficiency, and automation of large-scale model training and real-time inference systems, pioneering the LLM infrastructure required to support next-generation GenAI workloads at Amazon Ads scale. * Design and run rigorous A/B experiments to quantify the business and customer impact of GenAI-driven shopper insights, performing advanced statistical analysis to guide iterative production rollouts. * Conduct applied research in novel generative AI techniques (e.g., fine-tuning, RAG, agentic workflows) to optimize the shopper experience and drive performance across all aspects of the Sponsored Products and Brands business.
US, WA, Seattle
Interested in modeling and understanding customer behavior through machine learning, artificial intelligence, and data mining over TB scale data with huge business impact on millions of customers? Join our team of Scientists developing models to model customer behavior and optimize the customer experience with Amazon Prime. This includes understanding who our customers are, long-term value of the Prime membership program, and creating the right personalized framework for content and subscription optimization. As an AI/ML expert, you will partner directly with product owners to intake, build, and directly apply your modeling solutions. There are numerous scientific and technical challenges you will get to tackle in this role, such as optimizing/fine-tuning GenAI/LLM solutions for Prime personalization, building GenAI foundation models, global scalability of models, combinatorial optimization, cold start problem, accelerated experimentation, short/long term goals modeling, and multi-step optimization leading to reinforcement learning of the customer journey. We employ techniques from GenAI/LLMs, supervised/semi-supervised learning, deep learning, transformer architectures, using outcomes from causal Econometric modeling, and Reinforcement learning. As the central science team within Prime, our expertise gets routinely called upon to weigh in on a variety of topics. We also emphasize the need and value of scientific research and have developed a strong publication and patent record (internally/externally) which you will be a part of. You will also utilize and be exposed to the latest in ML technologies and infrastructure: AWS technologies (EMR/Spark, Sagemaker, DynamoDB, S3, ClaudeCode), various AI/ML algorithms and techniques (Deep Learning, GenAI/LLMs, transformers, supervised/unsupervised/semi-supervised/reinforcement learning), and statistical modeling techniques. - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems. Key job responsibilities Key job responsibilities - Stay abreast of current literature in the field and advance/build novel science solutions leveraging SoTA solutions. - Build and develop AI/ML models and supporting infrastructure at TB scale, in coordination with software engineering teams. - Leverage Deep Learning and GenAI solutions for building foundation models and personalized optimization solution. - Develop offline policy estimation tools and integrate with measurement systems/econometric models. - Establish scalable, efficient, automated processes for large scale data analyses, science development, science validation and model implementation. - Analyze and extract relevant information from large amounts of Amazon’s historical business data to help automate and optimize key processes. - Work closely with the business to understand their problem space, identify the opportunities and formulate the problems. - Use AI/machine learning, data mining, statistical techniques and others to create actionable, meaningful, and scalable solutions for the business problems. - Design, develop and evaluate highly innovative models and statistical approaches to understand and predict customer behavior and to solve business problems.
GB, London
In Amazon Advertising, we apply machine learning at massive scale to optimize the prediction, ranking, and bidding behind every ad — deciding, in milliseconds, which ads to show shoppers and how to value them. We're looking for an Applied Scientist to help make sure the ads shoppers see are the right ones for them. You'll work across the science of how we rank, value, and bid on ads for Amazon DSP (Amazon's Demand-Side Platform) — including how we judge whether an ad is a good fit for the page a shopper is on and for the shopper themselves. It's high-scale, low-latency, customer-facing science: your models run live in front of millions of shoppers under tight real-time constraints. The questions are genuinely open — how do you tell whether an ad is relevant to someone, how do you balance what's good for shoppers, advertisers, and Amazon, and how do you keep getting that right as shopping behavior and inventory shift underneath you? Your work will have real impact, and you'll have room to shape where we take it. A few things make this stand out: your models touch a huge share of the ads shoppers see every day, so even small improvements add up fast; you'll run modern ML live under strict latency limits, across regions and very different types of ad inventory; and the problem space is rich — from how we value and bid on ads, to keeping models stable as traffic shifts, to what makes an ad a good fit for a shopper. Key job responsibilities - Design and improve the models that decide how ads are ranked, valued, and priced — including how relevant an ad is to the page and the shopper. - Apply and extend state-of-the-art techniques across e.g. ranking, deep learning, and information retrieval. - Own problems end to end: frame them, prototype, experiment, and ship them to production. - Balance competing objectives — shopper experience, advertiser and publisher value, and Amazon's business — into models that hold up across placements and marketplaces. - Communicate your work clearly to both business and science audiences, tailoring how you share it to each. - Write and ship your own production code backed by strong engineering support — we're all builders here. - Move fast with the best tools available, including modern AI coding assistants and agents. A day in the life You might start by digging into last week's experiment results, then use an AI coding agent to get your next prototype built and ready to test in production. In the afternoon you could be sketching a new way to measure ad relevance, reading a recent paper that bears on it, and talking it through with a senior scientist on the team. You'll move between hands-on science, writing and shipping real production code, and making the calls on your own work. About the team We're a group of scientists and engineers based in Edinburgh and London, working to make Amazon's ads more performant and relevant. We sit within a larger team spread primarily across New York City and the UK, and we have a broad mandate to build and experiment. You'll work alongside senior applied scientists you can learn from, with the data and infrastructure to do the work well and room to grow — with opportunities to attend top conferences (e.g., NeurIPS, KDD, ICML) and take on more scope over time.
US, WA, Seattle
We are seeking a Principal Applied Scientist to own the scientific vision across Agentic WorkSpaces. This is a foundational role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will define how we measure, improve, and guarantee the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You will help define which ones we pursue. The problems you will solve do not have established industry patterns. You will set the direction for the science of how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. Key job responsibilities - Set the long-term scientific vision: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Identify the unsolved scientific problems, chart a multi-year research roadmap, and secure buy-in from VP-level leadership. - Solve highly ambiguous, novel problems: Independently frame and deliver solutions to foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. - Own the evaluation and measurement foundation: Build the benchmarks, datasets, and metrics that quantify agent and team accuracy, cost, productivity, and safety across the portfolio and diverse enterprise workflows, and that gate what we ship. - Drive cross-organizational scientific alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio to shape how models and agent frameworks are applied, and ensure scientific decisions compose into a coherent system. - Deliver measurable business impact: Ensure research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. - Raise the scientific bar: Establish rigor in experimentation, evaluation, and reproducibility. Mentor and grow senior scientists and engineers. Set the standard for applied science quality across the organization. - Advance the state of the art: Contribute to the external technical community through publications, patents, and open-source contributions that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
IN, KA, Bengaluru
Amazon Health Services (One Medical) About Us: At Health AI, we're revolutionizing healthcare delivery through innovative AI-enabled solutions. As part of Amazon Health Services and One Medical, we're on a mission to make quality healthcare more accessible while improving patient outcomes. Our work directly impacts millions of lives by empowering patients and enabling healthcare providers to deliver more meaningful care. Role Overview: We're seeking an Applied Scientist to join our dynamic team in building state of the art AI/ML solutions for healthcare. This role offers a unique opportunity to work at the intersection of artificial intelligence and healthcare, developing solutions that will shape the future of medical services delivery. Key job responsibilities • Lead end-to-end development of AI/ML solutions for Amazon Health organization, including Amazon Pharmacy and One Medical • Research, design, and implement state-of-the-art machine learning models, with a focus on Large Language Models (LLMs) and Visual Language Models (VLMs) • Optimize and fine-tune models for production deployment, including model distillation for improved latency • Drive scientific innovation while maintaining a strong focus on practical business outcomes • Collaborate with cross-functional teams to translate complex technical solutions into tangible customer benefits • Contribute to the broader Amazon Health scientific community and help shape our technical roadmap
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of pharma, biotech, and diagnostics customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an exceptional Principal Applied Scientist to set the scientific direction for our life sciences AI portfolio. You will be the scientific leader who defines research agendas, architects novel approaches, and delivers models and methods that give our customers capabilities that did not previously exist. This is a rare role that combines deep expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will innovate on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge in biology to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step scientific workflows? - How do you develop model customization and training methods that let customers get state-of-the-art results from foundation models? - How do you adapt and extend protein and antibody models so customers can fine-tune on proprietary sequence data and get therapeutically relevant outputs? You will work across drug discovery (protein engineering, antibody design) and clinical trial operations (agentic automation, structured reasoning, domain adaptation). You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that thousands of scientists use daily. Key job responsibilities - Set the scientific vision and research agenda for LLM reasoning, agentic AI, and biological model customization across the portfolio - Innovate on LLM reasoning, planning, and agentic approaches for complex scientific and regulatory workflows - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that enable customers to train better models on their own data with less effort - Advance methods to adapt and extend biological foundation models for customer-specific therapeutic applications - Solve open research problems in faithful reasoning, multi-step planning, and tool use in high-stakes scientific domains - Partner with Life Sciences domain experts and customers to understand their hardest scientific challenges and translate those into tractable research problems - Publish at top-tier venues and build the team's external scientific reputation - Mentor applied scientists across the team while maintaining significant personal research contribution - Collaborate with product and engineering to ensure research translates into shipped products that serve customers at scale - Influence multi-year research roadmaps through deep scientific expertise and customer understanding A day in the life - Push a new reasoning approach into production that measurably improves outputs for a pharma customer's workflow - Design and run experiments to validate a novel fine-tuning method, then ship it as a capability customers can use immediately - Unblock a delivery milestone by diagnosing why a model is failing on a new class of inputs and implementing a fix - Meet with a customer's scientific team to scope what the next model release needs to do for them - Review a teammate's experimental results, sharpen the approach, and help get it over the finish line - Publish results from shipped work at a top venue, closing the loop between research and impact - Prototype a new idea that could become the next major capability in the product
US, WA, Seattle
We are seeking a Senior Manager, Applied Science to build and lead the science organization across Agentic WorkSpaces. This is a foundational leadership role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will hire, grow, and lead a team of applied scientists who define how we measure and improve the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You and your team will define which ones we pursue. The problems your team will solve do not have established industry patterns. You will set the scientific direction and build the team that determines how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. What You Will Do Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Key job responsibilities Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Set the long-term scientific vision and team strategy: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Chart a multi-year research roadmap, and build the team and plan to deliver it. Secure buy-in from VP-level leadership. Hire and grow scientific talent: Own recruiting, calibration, development, and retention for the science team. Mentor scientists toward senior and principal scope, and raise the scientific bar across the organization. Direct research on highly ambiguous, novel problems: Guide the team through foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. Drive cross-organizational alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio, with product and engineering leadership, to ensure scientific decisions compose into a coherent product. Deliver measurable business impact: Ensure your team's research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. Establish scientific rigor and operational excellence: Set the standard for experimentation, evaluation, and reproducibility, and the mechanisms that keep the science organization productive and accountable. Advance the state of the art: Enable and champion contributions to the external technical community through publications, patents, and open-source work that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
IN, HR, Gurugram
Work on ML teams building large-scale forecasting and optimization systems that power Amazon’s global transportation network and directly impact customer experience and cost. As an Applied Scientist II, you will set scientific direction, mentor applied scientists, and partner with engineering and product leaders to deliver production-grade ML solutions at massive scale. Key job responsibilities 1. Lead and grow a high-performing team of Applied Scientists, providing technical guidance, mentorship, and career development. 2. Define and own the scientific vision and roadmap for ML solutions powering large-scale transportation planning and execution. 3. Guide model and system design across a range of techniques, including tree-based models, deep learning (LSTMs, transformers), LLMs, and reinforcement learning. 4. Ensure models are production-ready, scalable, and robust through close partnership with stakeholders. Partner with Product, Operations, and Engineering leaders to enable proactive decision-making and corrective actions. 5. Own end-to-end business metrics, directly influencing customer experience, cost optimization, and network reliability. 6. Help contribute to the broader ML community through publications, conference submissions, and internal knowledge sharing. A day in the life Your day includes reviewing model performance and business metrics, guiding technical design and experimentation, mentoring scientists, and driving roadmap execution. You’ll balance near-term delivery with long-term innovation while ensuring solutions are robust, interpretable, and scalable. Ultimately, your work helps improve delivery reliability, reduce costs, and enhance the customer experience at massive scale.
US, NY, New York
At Amazon Selection and Catalog Systems (ASCS), our mission is to power the online buying experience for customers worldwide so they can find, discover, and buy any product they want. We innovate on behalf of our customers to infer relationships between products in Amazon Catalog to drive the selection gateway for the search and browse experiences on the website. We're solving a fundamental AI challenge: establishing product identity and relationships at unprecedented scale. Using Generative AI, Visual Language Models (VLMs), and multimodal reasoning, we determine what makes each product unique and how products relate to one another across Amazon's catalog. The scale is staggering: billions of products, petabytes of multimodal data, millions of sellers, dozens of languages, and infinite product diversity—from electronics to groceries to digital content. The research challenges are immense. GenAI and VLMs hold transformative promise for catalog understanding, but we operate where traditional methods fail: ambiguous problem spaces, incomplete and noisy data, inherent uncertainty, reasoning across both images and textual data, and explaining decisions at scale. Establishing product identities and groupings requires sophisticated models that reason across text, images, and structured data—while maintaining accuracy and trust for high-stakes business decisions affecting millions of customers daily. Amazon's Item and Relationship Platform group is looking for an innovative and customer-focused applied scientist to help us make the world's best product catalog even better. In this role, you will partner with technology and business leaders to build new state-of-the-art algorithms, models, and services to infer product-to-product relationships that matter to our customers. You will pioneer advanced GenAI solutions that power next-generation agentic shopping experiences, working in a collaborative environment where you can experiment with massive data from the world's largest product catalog, tackle problems at the frontier of AI research, rapidly implement and deploy your algorithmic ideas at scale, across millions of customers. Key job responsibilities * Formulate novel research problems at the intersection of GenAI, multimodal learning, and large-scale information retrieval—translating ambiguous business challenges into tractable scientific frameworks * Design and implement leading models leveraging VLMs, foundation models, and agentic architectures to solve product identity, relationship inference, and catalog understanding at billion-product scale * Pioneer explainable AI methodologies that balance model performance with scalability requirements for production systems impacting millions of daily customer decisions * Own end-to-end ML pipelines from research ideation to production deployment—processing petabytes of multimodal data with rigorous evaluation frameworks * Define research roadmaps aligned with business priorities, balancing foundational research with incremental product improvements * Mentor peer scientists and engineers on advanced ML techniques, experimental design, and scientific rigor—building organizational capability in GenAI and multimodal AI * Represent the team in the broader science community—publishing findings, delivering tech talks, and staying at the forefront of GenAI, VLM, and agentic system research
US, WA, Seattle
Trusted by more startups around the world, AWS makes the power of cloud computing accessible for all by giving founders everywhere access to the same technology that powers the world's largest companies. With nearly two decades of experience supporting hundreds of thousands of startups, including 80% of unicorns, we democratize cloud computing to help founders bring their innovative ideas to life. We support founders at every stage of their journey, from initial onboarding and credit programs to AI-powered guidance and scale solutions. Data is central to how we do this: it helps us identify high-potential startups early, personalize the guidance we deliver, and prioritize where we can create the most value for founders and for AWS. We are seeking an Applied Science Manager to lead a team of applied scientists and analysts building the data and machine learning capabilities behind AWS Startups. You will own the science roadmap end-to-end, from the data foundation that unifies signals about founders, startups, and their products, through a portfolio of machine learning models, to the surfaces that put insights in the hands of the teams and products that serve startups. You will balance hands-on technical leadership with people management, setting the technical bar for your team while developing their careers. Key job responsibilities · Lead, coach, and grow a team of applied scientists, business intelligence engineers, and business analysts; hire and develop talent and set a high technical bar. · Own and prioritize the team's science roadmap and set technical direction for its machine learning models and data assets, balancing rapid experimentation with production quality, cost, and reliability. · Scope scientific projects, design and evaluate experiments, and productionize models that deliver measurable impact, establishing measurement, evaluation, and operational-excellence standards so quality and impact are quantified and defensible. · Drive the science behind recommendation systems, startup segmentation and targeting, and fraud detection, delivering models that surface relevant opportunities, group and prioritize startups by need and fit, and protect the business from fraud and abuse. · Partner with product, engineering, design, and go-to-market teams to translate science into scalable products, and communicate strategy, results, and trade-offs clearly to technical and non-technical leaders. · Foster a culture of scientific rigor and rapid experimentation, and proactively identify and escalate risks with clear mitigation plans. About the team The AWS Startups team builds innovative products and platforms that support startup customers throughout their journey, from initial onboarding and credit programs to AI-powered guidance and scale solutions. Our portfolio serves hundreds of thousands of startup customers globally, and we partner with business development, field marketing, and solutions architecture teams worldwide. We are building the next generation of AI-native products that make world-class cloud expertise accessible to every founder.