Line art of silicon chips developed by Annapurna Labs since its acquisition by Amazon in 2015.  Line art includes mentions of Graviton, Inferentia, and Trainium chips, along with AWS Nitro system.
Amazon's acquisition of Annapurna Labs in 2015 has led to, among other advancements, the development of five generations of the AWS Nitro system, three generations of Arm-based Graviton processors, as well as AWS Trainium and AWS Inferentia chips that are optimized for machine learning training and inference. These chips and systems were discussed at the AWS Silicon Innovation Day event on August 3. The event included a talk by Nafea Bshara, AWS vice president and distinguished engineer, on silicon innovation emerging from Annapurna Labs.

How silicon innovation became the ‘secret sauce’ behind AWS’s success

Nafea Bshara, AWS vice president and distinguished engineer, discusses Annapurna Lab’s path to silicon success; Annapurna co-founder was a featured speaker at AWS Silicon Innovation Day virtual event.

Nafea Bshara, Amazon Web Services vice president and distinguished engineer, and the co-founder of Annapurna Labs, an Israeli-based chipmaker that Amazon acquired in 2015, maintains a low profile, as does his friend and Annapurna co-founder, Hrvoye (Billy) Bilic.

Nafea Bshara headshot image
Nafea Bshara, AWS vice president and distinguished engineer.

Each executive’s LinkedIn profile is sparse, in fact, Bilic’s is out of date.

“We hardly do any interviews; our philosophy is to let our products do the talking,” explains Bshara.

Those products, and silicon innovations, have done a lot of talking since 2015, as the acquisition has led to, among other advancements, the development of five generations of the AWS Nitro System, three generations (1, 2, 3) of custom-designed, Arm-based Graviton processors that support data-intensive workloads, as well as AWS Trainium, and AWS Inferentia chips optimized for machine learning training and inference.

Some observers have described the silicon that emerges from Annapurna Labs in the U.S. and Israel as AWS’s “secret sauce”.

Nafea’s silicon journey began at Technion University in Israel, where he earned bachelor’s and master’s degrees in computer engineering, and where he first met Hrvoye. The two then went on to work for Israel-based Galileo, a company that made chips for networking switches, and controllers for networking routers. Galileo was acquired by U.S. semiconductor manufacturer Marvell in 2000, where Bshara and Bilic would work for a decade before deciding to venture out on their own.

“We had developed at least 50 different chips together,” Bshara explained, “so we had a track record and a first-hand understanding of customer needs, and the market dynamics. We could see that some market segments were being underserved, and with the support from our spouses, Lana and Liat, and our funding friends Avigdor [Willenz] and Manuel [Alba], we started Annapurna Labs.”

That was mid-2011, and three and half years later Amazon acquired the company. The two friends have continued their journey at Amazon, where their team’s work has spoken for itself.

Last year, industry analyst David Vellante praised AWS’s “revolution in system architecture.”

“Much in the same way that AWS defined the cloud operating model last decade, we believe it is once again leading in future systems. The secret sauce underpinning these innovations is specialized designs… We believe these moves position AWS to accommodate a diversity of workloads that span cloud, data center as well as the near and far edge.”

Annapurna’s work was highlighted during the AWS Silicon Innovation Day virtual event on August 3. In fact, Nafea was a featured speaker in the event. The Silicon Innovation Day broadcast, which highlighted AWS silicon innovations, included a keynote from David Brown, vice president, Amazon EC2; a talk about the history of AWS silicon innovation from James Hamilton, Amazon senior vice president and distinguished engineer who holds more than 200 patents in 22 countries in server and datacenter infrastructure, database, and cloud computing; and a fireside chat on the Nitro System with Anthony Liguori, AWS vice president and distinguished engineer, and Jeff Barr, AWS vice president and chief evangelist.

In advance of the silicon-innovation event, Amazon Science connected with Bshara to discuss the history of Annapurna, how the company and the industry have evolved in the past decade, and what the future portends.

  1. Q. 

    You co-founded Annapurna Labs just over 11 years ago. Why Annapurna?

    A. 

     I co-founded the company with my longtime partner, Billy, and with an amazing set of engineers and leaders who believed in the mission. We started Annapurna Labs because we looked at the way the chip industry was investing in infrastructure and data centers; it was minuscule at that time because everybody was going after the gold rush of mobile phones, smartphones, and tablets.

    We believed the industry was over indexing on investment for mobile, and under investing in the data center. The data center market was underserved. That, combined with the fact that there was increasing disappointment with the ineffective and non-productive method of developing chips, especially when compared with software development. The productivity of software developers had improved significantly in the past 25 years, while the productivity of chip developers hadn’t improved much since the ‘90s. In assessing the opportunity, we saw a data-center market that was being underserved, and an opportunity to redefine chip development with greater productivity, and with a better business model. Those factors contributed to us starting Annapurna Labs.

  2. Q. 

    How has the chip industry evolved in the past 11 years?

    A. 

    The chip industry realized, a bit late, but nevertheless realized that productivity and time to market needed to be addressed. While Annapurna has been a pioneer in advancing productivity and time to market, many others are following in our footsteps and transitioning to a building-blocks-centric development mindset, similar to how the software industry moved toward object-oriented, and service-oriented software design.

    Chip companies have now transitioned to what we refer to as an intellectual property-oriented, or IP-oriented, correct-by-design approach. Secondly, the chip industry has adopted the cloud. Cloud adoption has led to an explosion of compute power for building chips. Using the cloud, we are able to use compute in a ‘bursty’ way and in parallel. We and our chip-industry colleagues couldn’t deliver the silicon we do today without the cloud. This has led to the creation of a healthy market where chip companies have realized they don’t need to build everything in house, in much the same way software companies have realized they can buy libraries from open source or other library providers. The industry has matured to the point where now there is a healthy business model around buying building blocks, or IPs, from providers like Arm, Synopsys, Alphawave, or Cadence.

  3. Q. 

    Annapurna Labs was named after one of the tallest peaks in the Himalayas that’s regarded as one of the most dangerous mountains to climb. What's been the tallest peak you've had to climb?

    A. 

    I’m up in the cloud, I don’t need to climb anything [laughing]. Yes, Billy and I picked the name Annapurna Labs for a couple of reasons. First, Billy and I originally planned to climb Annapurna before we started the company. But then we got excited about the idea, acquired funding, and suddenly time was of the essence, so we put our climbing plans on hold and started the company. We called it Annapurna because at that time – and it’s true even today – there is a high barrier to entry in starting a chip company. The challenge is steep, and the risk is high, so it’s just like climbing Annapurna. We also believed that we wanted to reach a point above the clouds where you could see things very clearly, and without clutter. That’s always been a mantra for us as a company: Avoid the clutter, and look far into the future to understand what the customer really needs versus getting distracted by the day-to-day noise.

  4. Q. 

    What are the unique challenges you face in designing chips for ML training and inference versus more general CPU designs?

    A. 

    First, I would want to emphasize what challenge we didn’t have to worry about: with the strong foundation, methodologies, and engineering muscle we built delivering multiple generations of Nitro, we had confidence in our ability to execute on building the chips and manufacturing them at high volume, and high quality. So that was a major thing we didn’t need to worry about. Designing for machine learning is one the most challenging, but also the most rewarding tasks I've had the pleasure to participate in. There is an insatiable demand for machine learning right now, so anyone with a good product won’t have any issues finding customer demand. The demand is there, but there are a couple of challenges.

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    The first is that customers want ‘just works’ solutions because they have enough challenges to work on the science side. So they are looking for a frictionless migration from the incumbent, let's say GPU-based machine learning, to AWS Trainium or AWS Inferentia. Our biggest challenge is to hide all the complexity so it’s what we refer to internally as boring to migrate. We don’t want our customers, the scientists and researchers, to have to think about moving from one piece of hardware to another. This is a challenge because the incumbent GPUs, specifically NVIDIA, have done a very good job developing broadly adopted technologies. The customer shouldn’t see or experience any of the hard work we’ve done in developing our chips; what the customer should experience is that it’s transparent and frictionless to transition to Inferentia and Trainium. That’s a hefty task and one of our internal challenges as a team.

    Trainium artwork from AWS website
    "The customer shouldn’t see or experience any of the hard work we’ve done in developing our chips; what the customer should experience is that it’s transparent and frictionless to transition to Inferentia and Trainium," says Bshara.

    The second challenge is more external; it’s the fact that science and machine learning are moving very fast. As an organization that is building hardware, our job is to predict what customers will need three, four, five years down the road because the development cycle for a chip can be two years, and then it gets deployed for three years. The lifecycle is around five years and trying to predict how the needs of scientists and the machine-learning community will evolve over that time span is difficult. Unlike CPU workloads, which aren’t evolving very quickly, machine learning workloads are, and it’s a bit of an art to keep apace. I would give ourselves a high score, not a perfect score, in being efficient in terms of execution and cost, while still being future proof. It’s the art of predicting what customers will need three years from now, while still executing on time and budget. These things only come with experience, and I’m fortunate to be part of a great team that has the experience to strike the right balance between cost, schedule, and future-proofing the product.

  5. Q. 

    At the recent re:MARS conference Rohit Prasad, Amazon senior vice president and Alexa head scientist, said the voice assistant is interacting with customers billions of times each week. Alexa is powered by EC2 Inf1 instances, which use AWS Inferentia chips. Why is it more effective for Alexa workloads to take advantage of this kind of specialized processing versus more general-purpose GPUs?

    A. 

    Alexa is one of those Amazon technologies that we want to bring to as many people as possible. It’s also a great example of the Amazon flywheel; the more people use it, the more value it delivers. One of our goals is to provide this service with as low latency as possible, and at the lowest cost possible, and over time improve the machine-learning algorithms behind Alexa. When people say improving Alexa, it really means handling much more complex machine learning, much more sophisticated models while maintaining the performance, and low latency. Using Inferentia, the chip, and Inf1, the EC2 instances that actually hosts all of these chips, Alexa is able to run much more advanced machine learning algorithms at lower costs and with lower latency than a standard general-purpose chip. It's not that the general-purpose chip couldn't do the job, it's that it would do so at higher costs and higher latency. With Inferentia we deliver lower latency and support much more sophisticated algorithms. This results in customers having a better experience with Alexa, and benefitting from a smarter Alexa.

  6. Q. 

    AI has been called the new electricity. But as ML models become increasingly large and complex as you just discussed, there also are concerns that energy consumption for AI model training and inference is damaging to the environment. At the chip level, what can be done to reduce the environmental impact of ML model training and Inference?

    A. 

    What we can do at the chip level, at the EC2 level, is actually work on three vectors, which we’re doing right now. The first is drive to lower power quickly by using more advanced silicon processes. Every time we build a chip in an advanced silicon process we're utilizing new semiconductor processes with smaller transistors that require less power for the same work. Because of our focus on efficient execution, we can deliver to EC2 customers a new chip based on a more modern, power-efficient silicon process every 18 months or so.

    The second vector is building more technologies, trying to accelerate in hardware and in algorithms, to get training and inference done faster. The faster we can handle training and inference, the less power is consumed. For example, one of the technologies we innovated in the last Trainium chip was something called stochastic rounding which, depending upon which measure you're looking at for some neural workloads, could accelerate neural network training by up to 30%. When you say 30% less time that translates into 30% less power.

    Another thing we're doing at the algorithmic level is offering different data types. For example, historically machine learning used a 32-bit floating point. Now we’re offering multiple versions of 16-bit and a few versions of 8-bit. When these different data types are used, they not only accelerate machine learning training, they significantly reduce the power for the same amount of workload. For example, doing matrix multiplication on a 16-bit float point is less than one-third the total power if we had done it with 32-bit floating point. The ability to add things like stochastic rounding or new data types at the algorithmic level provides a step-function improvement in power consumption for the same amount of workload.

    The third vector is credit to EC2 and the Nitro System, we’re offering more choice for customers. There are different chips optimized for different workloads, and the best way for customers to save energy is to follow the classic Amazon mantra – the everything store. We offer all different types of chips, including multiple generations of Nvidia GPUs, Intel Habana, and Trainium, and share with the customer the power profile and performance of each of the instances hosting these chips, so the customer can choose the right chip for the right workload, and optimize for the lowest possible power consumption at the lowest cost.

  7. Q. 

    I’ve focused primarily on machine learning. But let’s turn our attention to more general-purpose workloads running in the cloud, and your work on Graviton processors for Amazon EC2. 

    A. 

    Yes, in a way Graviton is the opposite of our work on machine learning, in the sense that the focus is on building server processors for general-purpose workloads running in EC2. The market for general-purpose chips has been there for thirty or forty years, and the workloads themselves haven’t evolved as rapidly as machine learning, so when we started designing, the target was clear to us.

    This is an image of a Graviton silicon chip with a blue background.
    AWS is three generations into its Graviton chip journey, and Bshara says the company has plans for "many more generations" to come.

    Because this segment of the industry wasn’t moving that fast, we felt our challenge was to move the industry faster, specifically in offering step function improvement in performance, and reducing costs, and power consumption. There are many times when you build plans, especially for chips, where the original plans are rosy, but as the development progresses you have to make tradeoffs, and the actual product falls short of the original promise. With first-generation Graviton, we experienced the opposite; we were pleasantly surprised that both performance and power efficiency turned out better than our original plan. That’s very rare in our industry.

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    The same has been true with Graviton2. Because of this there has been a massive movement inside Amazon for general workloads to move to Graviton2, mainly to save on power, but also on costs. For the same workloads, Graviton2 will on average consume 60% less power than same-generation competitive offerings, and we’re passing on those cost-savings to customers. Outside Amazon, at least 48 of AWS’s top 50 customers have not just tested, but have production workloads running on Graviton2.

    In May, Graviton3 processors became available, so it’s still Day 1 as we’re only three generations into this journey. We have plans for many more generations, but it’s always very satisfying and rewarding to hear how boring it is for customers to migrate to Graviton, and to hear all the customer success stories. It is incredibly satisfying to come to work every day and hear some of the success stories from the tens of thousands of customers using Graviton.

  8. Q. 

    You have more than 100 openings on your jobs page. What kind of talent are you seeking? And what are the characteristics of employees who succeed at Annapurna Labs? 

    A. 

    We are seeking individuals who like to work on cutting-edge technology, and approach challenges from a principles-first approach because most of the challenges we confront haven’t been dealt with before. While actual experience is important, we place greater value on proper thinking and a principles-first mindset, or reasoning from first principles.

    We also value individuals who enjoy working in a dynamic environment where the solution isn’t always the same hammer after the same nail. Given our principles-first approach, many of our challenges get solved at the chip level, the terminal level, and the system level, so we seek individuals who have systems understanding, and are skilled at working across disciplines. It’s difficult for an individual with a single discipline, or single domain knowledge, who isn’t willing to challenge her or himself by learning across other domains, to succeed at Annapurna. Last but not least, we look for individuals who focus on delivering, within a team environment. We recognize ideas are “cheap”, and what makes the difference is delivering on the idea all the way to production. Ideas are a commodity. Executing on those ideas is not.

  9. Q. 

    I've read that Billy and you share the belief that if you can dream it, you can do it. So what's your dream about future silicon development?

    A. 

    That’s true, and it’s the main reason Billy and I wanted to join AWS, because we had a common vision that there’s so much value we can bring to customers, and AWS leadership and Amazon in general were willing to invest in that vision for the long term. We agreed to be acquired by Amazon not only because of the funding and our common long-term vision, but also because building components for our own data centers would allow us to quickly deliver customer value. We’ve been super happy with the relationship for many reasons, but primarily because of our ability to have customer impact at global scale.

    At Amazon, we operate at such a scale and with such a diversity of customers that we are capable of doing application-specific, or domain-specific acceleration. Machine learning is one example of that. What we’ve done with Aqua (advanced query accelerator) for Amazon Redshift is another example where we’ve delivered hardware-based acceleration for analytics. Our biggest challenge these days is deciding what project to prioritize. There’s no shortage of opportunities to deliver value. The only way we’re able to take this approach is because of AWS. Developing silicon requires significant investment, and the only way to gain a good return on that investment is by having a lot of volume and cost-effective development, and we’ve been able to develop a large, and successful customer base with AWS.

    I should also add that before joining Amazon we thought we really took a long-term perspective. But once you sit in Amazon meetings, you realize what long-term strategic thinking really means. I continue to learn every day about how to master that. Suffice to say, we have a product roadmap, and a technology and investment strategy that extends to 2032. As much uncertainty as there is in the future, there are a few things we’re highly convicted in, and we’re investing in them, even though they may be ten years out. I obviously can’t disclose future product plans, but we continue to dream big on behalf of our customers.

    The AWS Annapurna Labs team has more than 100 job openings for software developers, physical design engineers, design specification engineers, and many other technical roles. The team has development centers in the U.S. and Israel.

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We are seeking Data Scientist II with strong science application skills to join our Device Economics team. This role will focus primarily on Amazon's innovative devices and services (e.g. Echo Family of Devices), working at the intersection of economic modeling, forecasting science, and business strategy. The ideal candidate will be responsible for pre-launch forecasts, annualized overall forecasts, identifying substitution patterns, and partnering closely with product managers and marketing managers to understand the evolution of the Devices portfolio. Key job responsibilities Forecasting & Modeling 1. Develop and maintain pre-launch forecasts and annualized overall forecasts for Amazon Devices 2. Identify and model substitution patterns across the device portfolio 3. Build economic and financial models to support demand planning and business decisions 4. Formulate relevant analytical frameworks to address key economic issues in device forecasting Science Communication & Collaboration 1. Explain complex science models and methodologies to non-technical stakeholders including product managers and marketing managers 2. Collaborate with economists, data scientists, and applied scientists across Decision Science 3. Present results of analyses to cross-functional teams and leadership 4. Build trust in science models and forecast outputs with product teams Innovation & Strategic Thinking 1. Think creatively about ways that leading-edge analytics and emerging data sources can address Devices' most pressing business challenges 2. Help internal teams leverage analytic tools to better manage innovation 3. Conduct empirical studies and perform quantitative and qualitative research 4. Identify opportunities to improve forecasting accuracy and business impact Cross-Functional Partnership 1. Work closely with product managers and marketing managers to understand portfolio evolution and business strategy 2. Support DSO leadership in quarterly business reviews and strategic planning A day in the life Your days will be split between refining and building models and working with business leaders to interpret them. You own science-based forecasts that can directly impact Amazon's bottom line on the order of multi-million dollar decisions. - You will perform model refreshes or updates to analyses as needed; and, - You will be expected to develop new techniques to process large data sets, address quantitative problems, and contribute to design of automated systems. About the team The Decision Science team within DSO (Device Supply Organization) is responsible for forecasting and demand planning initiatives across Amazon Devices. The DSO team of 300+ engineers, scientists, and PMs applies quantitative methods and data-driven approaches to replace judgment-based decisions with science-driven forecasts. Decision Science focuses on lifetime demand forecasting using econometric and machine learning models for rapid reforecasting, mix adjustments, and portfolio management for new product launches. We also inform to go/no-go investment decision for new product initiatives
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide business applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are no-brainers to buy and easy to use. We are looking for an Applied Scientist to join our team that is building enterprise applications leveraging machine learning, generative AI, and agentic AI to help millions of companies worldwide manage their day-to-day supply chain operations. Our mission is to accelerate our customers' businesses through intuitive, differentiated technology solutions that solve enduring supply chain challenges. We blend strategic vision with curiosity and Amazon's real-world operational experience to build opinionated, turnkey solutions that make the 'buy versus build' decision a no-brainer for our customers. As an Applied Scientist, you will design and develop machine learning models and algorithms that power intelligent supply chain applications at global scale. You will work at the intersection of research and real-world product impact, translating scientific advances into production systems that serve millions of customers. We operate like a startup within AWS, offering you the opportunity to tackle complex challenges while working with the latest technologies in deep learning, large language models, and optimization. If you are passionate about pushing the boundaries of applied science, thrive in ambiguous problem spaces, and want to shape the future of supply chain intelligence while having the backing of AWS's extensive resources, we want to hear from you. Key job responsibilities - Design, develop, and deploy machine learning models for demand forecasting, inventory optimization, anomaly detection, and supply chain decision-making. - Develop generative AI and agentic AI solutions that automate complex supply chain workflows and deliver intelligent, adaptive recommendations to customers. - Formulate real-world business problems as machine learning problems; define data requirements, model architectures, evaluation metrics, and experimentation frameworks. - Drive end-to-end applied science projects from ideation through experimentation, offline evaluation, A/B testing, and production deployment at scale. - Collaborate with engineering, product management, and business stakeholders to translate scientific capabilities into customer-facing product features, and mentor other scientists to raise the team's technical bar. A day in the life You will start many mornings reviewing experiment results and model metrics before joining a science sync where you and your teammates discuss progress, debug tricky modeling issues, and brainstorm new approaches. From there, you may spend focused time writing and testing model code in Python or PyTorch, running offline evaluations, or preparing an A/B test for a new forecasting algorithm. Expect regular working sessions with software engineers to integrate your models into production services, and occasional deep-dive reviews where you present your scientific approach and findings to the broader team. About the team The AWS Applied AI Solutions team builds enterprise applications that leverage Amazon's operational expertise to solve real-world supply chain challenges for millions of companies. We operate like a startup within AWS, moving fast and shipping iteratively with modern AI technologies. We invest in your growth through mentorship from experienced scientists, conference publication support, and internal science reading groups. If your career hasn't followed a traditional path, we encourage you to apply — we value varied experiences and perspectives.
US, NY, New York
We are seeking a Lead Applied Scientist to drive the development of next-generation manipulation and autonomy systems for robots operating in complex, real-world environments. This role is designed for an exceptional technical leader with a strong research background and a passion for translating cutting-edge ideas into working robotic systems. You will play a central role in defining the technical direction of our manipulation and autonomy stack, from problem formulation and algorithm design to system integration and real-world deployment. While this role is hands-on and deeply technical, it is also expected to evolve toward technical leadership and team building over time. Key job responsibilities - Lead research and development of manipulation and autonomy systems for robots, including planning, control, learning, and closed-loop execution - Design and implement algorithms, especially focused around autonomy and interaction with dynamic environments - Work closely with perception, motor control, hardware, and systems teams to build tightly integrated autonomy pipelines - Define evaluation methodologies, benchmarks, and simulation-to-real workflows for manipulation and autonomy - Stay deeply engaged with the research community, selectively incorporating state-of-the-art techniques into deployed systems - Mentor and guide other researchers and engineers, help set technical direction, and contribute to team growth and research culture - Lead technical projects from conception through production deployment - Bridge research initiatives with practical engineering implementation About the team Fauna Robotics, an Amazon company, is building capable, safe, and genuinely delightful robots for everyday life. Our goal is simple: make robots people actually want to live and interact with in everyday human spaces. We believe that future won’t arrive until building for robotics becomes far more accessible. Today, too much effort is spent reinventing the fundamentals. We’re changing that by developing tightly integrated hardware and software systems that make it faster, safer, and more intuitive to create real-world robotic products. Our work spans the full stack: mechanical design, control systems, dynamic modeling, and intelligent software. The focus is not just functionality, but experience. We’re building robots that feel responsive, expressive, and genuinely useful. At Fauna, you’ll work at the frontier of this space, helping define how robots move, manipulate, and interact with people in natural environments. It’s an opportunity to solve hard problems across hardware and software with a team focused on making robotics accessible and joyful to build. If you care about making robotics real for everyone and building systems that are as delightful as they are capable, we’re interested in hearing from you.
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an Applied Scientist to build the models and methods behind our life sciences AI products, with a primary focus on clinical trial operations and agentic reasoning. You will design, train, and evaluate systems that reason over complex clinical and operational logic, and ship them into products customers use directly. You will work closely with senior and principal scientists on well-scoped research problems, own your results end to end, and see your work reach production. This role combines expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will work on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step operational workflows? - How do you evaluate agent reliability and faithfulness rigorously enough to trust in high-stakes clinical settings? - How do you develop model customization methods (fine-tuning, retrieval augmentation, domain adaptation) that let customers get strong results from foundation models on their own data? You will focus on clinical trial operations (agentic automation, structured reasoning, evaluation, domain adaptation), with opportunities to contribute across drug discovery (protein engineering, antibody design) as the portfolio grows. You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that scientists use daily. Key job responsibilities - Design, train, fine-tune, and evaluate LLM-based agentic systems that reason over clinical protocols, regulatory standards, and operational workflows - Build rigorous evaluation harnesses and benchmarks to measure agent reliability, faithfulness, and failure modes in high-stakes domains - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that help customers get better outputs on their own data with less effort - Contribute to graph-based and causal modeling approaches for clinical trial operations - Partner with Life Sciences domain experts, product, and engineering to translate scientific challenges into shipped capabilities - Own experiments end to end: problem framing, implementation, evaluation, iteration, and hand-off to production - Publish at top-tier venues where the work supports it - Contribute to drug discovery efforts (protein engineering, antibody design) as opportunities arise A day in the life - Design and run an experiment to validate a new agentic reasoning or fine-tuning method, then ship it as a capability customers can use - Diagnose why a model is failing on a new class of inputs and implement a fix to unblock a delivery milestone - Build or extend an evaluation benchmark to measure how faithfully an agent reasons over clinical logic - Meet with domain experts to scope what the next model release needs to do - Review results with a senior scientist, sharpen the approach, and get it over the finish line - Prototype a new idea that could become the next capability in the product About the team AWS Solutions As part of the AWS solutions organization, we have a vision to provide business applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. we blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are no-brainers to buy and easy to use. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why AWS? Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture AWS values curiosity and connection. Our employee-led and company-sponsored affinity groups promote inclusion and empower our people to take pride in what makes us unique. Our inclusion events foster stronger, more collaborative teams. Our continual innovation is fueled by the bold ideas, fresh perspectives, and passionate voices our teams bring to everything we do. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve.
US, CA, Pasadena
As a Senior Quantum Applied Scientist on our Device team, you will be a technical authority and driving force in the design and measurements of novel superconducting qubits. You will lead detailed simulation and measurement efforts to explain experimental results, inform new qubit designs, and optimize device performance, working collaboratively with our design, fabrication, processor, and exploratory research teams. This is a role with significant room for innovation: you will play a key role in finding paths towards more performant devices. We are looking for a seasoned researcher with deep expertise in superconducting circuit physics plus a proven track record of bridging design, simulation, and measurement. Success in this role requires both technical depth and a genuine passion for applied, collaborative work. The ideal candidate will excel at communication across disciplines — translating detailed analyses into actionable guidance for engineering teams — and will bring the experience and judgment to identify innovations that will have the greatest impact. Key job responsibilities • Develop simulations to predict device performance, then design and measure devices that leverage the understood scalings. • Reduce the gap between simulated predictions and measurements by building more accurate models. • Communicate scientific findings across the CQC, and, when appropriate, share results externally via conference presentations and publications in scientific journals • Identify and evaluate emerging research developments that could impact design decisions About the team The Amazon Center for Quantum Computing (CQC) is a multi-disciplinary team of scientists, engineers, and technicians, on a mission to develop a fault-tolerant quantum computer.
IN, KA, Bengaluru
Amazon Pay strives to be Earth’s most customer-centric payments service. Our mission is to serve customers and merchant partners with the most trusted, friction-less and rewarding payment solutions for their needs on and off Amazon. We are seeking an exceptional Data Scientist III to drive innovation in machine learning and artificial intelligence solutions while leading high-impact initiatives across the organization. Key job responsibilities Technical Excellence Lead end-to-end machine learning projects using PyTorch, AWS SageMaker, and other leading ML frameworks Design and implement complex statistical models and deep learning solutions Develop and optimize MLOps pipelines for model training, evaluation, and deployment Experience with modern LLM frameworks and Generative AI applications Expertise in Python, R, and related data science libraries MLOps & Development Build automated ML pipelines using AWS services (CodePipeline, Lambda, Step Functions) Implement CI/CD practices for ML model deployment and monitoring Create containerized solutions using Docker for scalable model deployment Experience with model optimization and hyperparameter tuning using tools like Optuna Integrate ML solutions with monitoring tools like MLflow Business Impact & Leadership Partner with stakeholders to translate business problems into technical solutions Design and develop business intelligence applications for real-time insights Lead technical initiatives and mentor junior data scientists Drive cross-functional collaboration to deliver innovative solutions Communicate complex technical concepts to non-technical audiences About the team The Amazon Pay Data Products team is a central unit that builds and maintains data products supporting Amazon Pay's growth across multiple markets. We operate at scale, processing 150M+ monthly transactions and managing 12 PB of data infrastructure. Our team consists of Business Intelligence Engineers, Data Engineers, and Product Managers who develop and maintain standardized reporting, data marts, and self-service analytics tools. Our expanded capabilities cover data science and Gen AI wherein we have built our first suite of multi-agent systems.