Card-Imbens 16x9.jpg
David Card (left), an Amazon Scholar, a professor of economics at the University of California, Berkeley, and the outgoing president of the AEA, and Guido Imbens (right), an academic research consultant at Amazon and a professor at the Stanford Graduate School of Business.

A conversation with economics Nobelists

Amazon Scholar David Card and academic research consultant Guido Imbens on the past and future of empirical economics.

The annual meeting of the American Economic Association (AEA) took place Jan. 7 - 9, and as it approached, Amazon Science had the chance to interview two of the three recipients of the 2021 Nobel Prize in economics — who also happen to be Amazon-affiliated economists.

David Card, an Amazon Scholar, a professor of economics at the University of California, Berkeley, and the outgoing president of the AEA, won half the prize “for his empirical contributions to labor economics”.

Guido Imbens, an academic research consultant at Amazon and a professor at the Stanford Graduate School of Business, shared the other half of the prize with MIT’s Josh Angrist for “methodological contributions to the analysis of causal relationships”.

Amazon Science: The empirical approach to economics has been recognized by the Nobel Prize committee several times in the last few years, but it wasn't always as popular as it is today. I'm curious how you both first became interested in empirical approaches to economics.

David Card: The heroes of economics for many, many decades were the theorists, and in the postwar era especially, there was a recognition that economic modeling was underdeveloped — the math was underdeveloped — and there was a need to formalize things and understand better what the models really delivered.

People started to realize that we had the data to better look at real labor market phenomena and possibly make economics something different than just a kind of a branch of philosophy.
David Card

That need really proceeded through the ’60s, and Arrow and Debreu were these famous mathematical economists who developed some very elegant theoretical models of how the market works in an idealized economy.

What happened in my time was people started to realize that we had the data to better look at real labor market phenomena and possibly make economics something different than just a kind of a branch of philosophy. Arrow-Debreu is basically mathematical philosophy.

Guido Imbens: I came from a very different tradition. I grew up in the Netherlands, and there was a strong tradition of econometrics started by people like Tinbergen. Tinbergen had been very broad — he did econometrics, but he also did empirical work and was very heavily involved in policy analysis. But over time, the program he had started was becoming much more focused on technical econometrics.

So as an undergraduate, we didn't really do any empirical work. We really just did a lot of mathematical statistics and some operations research and some economic theory. My thesis was a theoretical econometrics study.

When I presented that at Harvard, Josh Angrist wasn't really all that impressed with it, and he actually opposed the department hiring me there because he thought the paper was boring. And he was probably right! But luckily, the more senior people there at the time thought I was at least somewhat promising. And so I got hired at Harvard. But then it was really Josh and Larry Katz, one of the labor economists there, who got me interested in going to the labor seminar and got me exposed to the modern empirical work.

The context Josh and I started talking in really was this paper that I think came up in all three of the Nobel lectures, this paper by Ed Leamer, “Let's Take the Con Out of Econometrics”, where Leamer says, “Hardly anyone takes data analysis seriously. Or perhaps more accurately, hardly anyone takes anyone else’s data analysis seriously.”

And I think Leamer was right: people did these very elaborate things, and it was all showing off complicated technical things, but it wasn't really very credible. In fact, Leamer presented a lecture based on that work at Harvard. And I remember Josh getting up at some point and saying, “Well, you talk about all this old stuff, but look at the work Card does. Look at the work Krueger does. Look at the work I do. It's very different.”

And that felt right to me. It felt that the work was qualitatively very different from the work that Ed Leamer was describing and that he was complaining about.

AS: So that's when you first became aware of Professor Card’s work. Professor Card, when did you first become aware of Professor Imbens’s work?

Card: One of his early papers was pretty interesting. He was trying to combine data from micro survey evidence with benchmark numbers that you would get from a population, and it's actually a version of a kind of a problem that arises at Amazon all the time, which is, we've got noisy estimates of something, and we've got probably reliable estimates of some other aggregates, and there's often ways to try and combine those. I saw that and I thought that was very interesting.

Then there’s the problem that Josh and Guido worked on that was most impactful and that was cited by the Nobel Prize committee. I had worked on an experiment, a real experiment [as opposed to a natural experiment], in welfare analysis in Canada, and it was providing an economic incentive to try and get single mothers off of welfare and into work. And we noticed that the group of mothers who complied or followed on with the experiment was reasonable size, but it wasn't 100%.

We did some analysis of it trying to characterize them. Around the same time, I became aware of Imbens’s and Angrist’s paper, which basically formalized that a lot better and described what exactly was going on with this group. That framework just instantly took off, and everyone within a few years was thinking about problems that way.

This morning I was talking to another Amazon person about a problem. It was a difference analysis. I was saying we should try and characterize the compliers for this difference intervention. So it's exactly this problem.

The Nobel committee’s press release for Card, Imbens, and Angrist’s prize announcement emphasizes their use of natural experiments, which it defines as “situations in which chance events or policy changes result in groups of people being treated differently, in a way that resembles clinical trials in medicine.” A seminal instance of this was Card’s 1993 paper with his Princeton colleague Alan Krueger, which compared fast-food restaurants in two demographically similar communities on either side of the New Jersey-Pennsylvania border, one of which had recently seen a minimum-wage hike and one of which hadn’t.

AS: In the early days, there was skepticism about the empirical approach to economics. So every time you selected a new research project, you weren't just trying to answer an economics problem; you were also, in a sense, establishing the credibility of the approach. How did you select problems then? Was there a structure that you recognized as possibly lending itself to natural experiment?

Card: I think that the natural-experiment thing — there was really a brief period where that was novel, to tell you the truth. Maybe 1989 to 1992 or 3. I did this paper on the Mariel boatlift, which was cited by the committee. But to tell you the truth, that was a very modest paper. I never presented it anywhere, and it's in a very modest journal. So I never thought of that paper as going anywhere [laughs].

What happened was, it became more and more well understood that in order to make a claim of causality even from a natural-experiment setting, you had to have a fair amount of information from before the experiment took place to validate or verify that the group that you were calling the treatment group and the group that you were calling the control group actually were behaving the same.

That was a weakness of the project that Alan Krueger and I did. We had restaurants in New Jersey and Pennsylvania. We knew the minimum wage was going to increase — or we thought we knew that; it wasn't entirely clear at the time — but we surveyed the restaurants before, and then the minimum wage went up, and we surveyed them after, and that was good.

But we didn't really have multiple surveys from before to show that in the absence of the minimum wage, New Jersey and Pennsylvania restaurants had tracked each other for a long time. And these days, that's better understood. At Amazon for instance, people are doing intervention analyses of this type. They would normally look at what they call pre-trend analysis, make sure that the treatment group and the control group are trending the same beforehand.

I think there are 1,000 questions in economics that have been open forever. Sometimes new datasets come along. That's been happening a lot in labor economics: huge administrative datasets have become available, richer and richer, and now we're getting datasets that are created by these tech firms. So my usual thing is, I think, that's a dataset that maybe we can answer this old question on. That’s more my approach.

That's why being at Amazon has been great .... A lot of people have substantive questions they're trying to analyze with data, and they're kind of stuck in places, so there's a need for new methodologies.
Guido Imbens

Imbens: I come from a slightly different perspective. Most of my work has come from listening to people like David and Josh and seeing what type of problems they're working on, what type of methods they're using, and seeing if there's something to be added there — if there’s some way of improving the methods or places where maybe they're stuck, but listening to the people actually doing the empirical work rather than starting with the substantive questions.

That's why being at Amazon has been great, from my perspective. A lot of people have substantive questions they're trying to analyze with data, and they're kind of stuck in places, so there's a need for new methodologies. It's been a very fertile environment for me to come up with new research.

AS: Methodologically, what are some of the outstanding questions that interest you both?

Imbens: Well, one of the things is experimental design in complex environments. A lot of the experimental designs we’re using at the moment still come fairly directly from biomedical settings. We have a population, we randomize them into a treatment group and a control group, and then we compare outcomes for the two groups.

But in a lot of the settings we’re interested in at Amazon, there are very complex interactions between the units and their experiences, and dealing with that is very challenging. There are lots of special cases where we know somewhat what to do, but there are lots of cases where we don't know exactly what to do, and we need to do more complex experiments to get the answers to the questions we're interested in.

Double randomization — original color scheme.jpeg
An example of what Imbens calls “experimental design in complex environments”. In this illustration, each of five viewers is shown promotions for eight different Prime Video shows. Some of those promotions contain extra information, indicated in the image by star ratings (the “treatment”). This design helps determine whether the treatment affects viewing habits (the viewer experiment) but also helps identify spillover effects, in which participation in the viewer experiment influences the viewer’s behavior in other contexts.

The second thing is, we do a lot of these experiments, but often the experiments are relatively small. They’re small in duration, and they’re small in size relative to the overall population. You know, it goes back to the paper we mentioned before, combining this observational-study data with experimental data. That raises a lot of interesting methodological challenges that I spend a lot of time thinking about these days.

AS: I wondered if in the same way that in that early paper you were looking at survey data and population data, there's a way that natural experiments and economic field experiments can reinforce each other or give you a more reliable signal than you can get from either alone.

Card: There's one thing that people do; I've done a few of these myself. It's called meta analysis. It's a technique where you take results from different studies and try and put them into a statistical model. In a way it's comparable to work Guido has done at Amazon, where you take a series of actual experiments, A/B experiments done in Weblab, and basically combine them and say, “Okay, these aren't exactly the same products and the same conditions, but there's enough comparability that maybe I can build a model and use the information from the whole set to help inform what we're learning from any given one.”

And you can do that in studies in economics. For example, I’ve done one on training programs. There are many of these training programs. Each of them — exactly as Guido was saying — is often quite small. And there are weird conditions: sometimes it's only young males or young females that are in the experiment, or they don't have very long follow-up, or sometimes the labor market is really strong, and other times it's really weak. So you can try and build a model of the outcome you get from any given study and then try and see if there are any systematic patterns there.

Imbens: We do all these experiments, but often we kind of do them once, and then we put them aside. There's a lot of information over the years built up in all these experiments we've done, and finding more of these meta-analysis-type ways of combining them and exploiting all the information we have collected there — I think it's a very promising way to go.

AS: How can empirical methods complement theoretical approaches — model building of the kind that, in some sense, the early empirical research was reacting against?

Card: Normally, if you're building a model, there are a few key parameters, like you need to get some kind of an elasticity of what a customer will do if faced with a higher price or if offered a shorter, faster delivery speed versus slower delivery speed. And if you have those elasticities, then you can start building up a model.

If you have even a fairly complicated dynamic model, normally there's a relatively small number of these parameters, and the value of the model is to take this set of parameters and try and tell a bit richer story — not just how the customer responds to an offer of a faster delivery today but how that affects their future purchases and whether they come back and buy other products or whatever. But you need credible estimates of those elasticities. It's not helpful to build a model and then just pull numbers out of the air [laughs]. And that's why A/B experiments are so important at Amazon.

AS: I asked about outstanding methodological questions that you're interested in, but how about economic questions more broadly that you think could really benefit from an empirical approach?

Card: In my field [labor economics], we've begun to realize that different firms are setting different wages for the same kinds of workers. And we're starting to think about two issues related to that. One is, how do workers choose between jobs? Do they know about all the jobs out there? Do they just find out about some of the jobs? We're trying to figure out exactly why it's okay in the labor market for there to be multiple wages for a certain class of workers. Why don't all the workers immediately try to go to one job? This seems to be a very important phenomenon.

And on the other side of that, how do employers think about it? What are the benefits to employers of a higher wage or lower wage? Is it just the recruiting, or is it retention, or is it productivity? Is it longer-term goals? That's front and center in the research that I do outside of Amazon.

AS: I was curious if there were any cases where a problem presented itself, and at first you didn't think there was any way to get an empirical handle on it, and then you figured out that there was.

We're supposed to be social scientists who are trying to see what people are doing and the problems they confront and trying to analyze them. ... That's different than this old-fashioned Adam Smith view of the economy as a perfectly functioning tool that we're just supposed to admire.
David Card

Card: I saw a really interesting paper that was done by a PhD student who was visiting my center at Berkeley. In European football, there are a lot of non-white players, and fan racism is pretty pervasive. This guy noticed that during COVID, they played a lot of games with no fans. So he was able to compare the performance of the non-white and white players in the pre-COVID era and the COVID era, with and without fans, and showed that the non-white players did a little bit better. That's the kind of question where you’re saying, How are we ever going to study that? But if you're thinking and looking around, there's always some angle that might be useful.

Imbens: That's a very clever idea. I agree with David. If you just pay attention, there are a lot of things happening that allow you to answer important questions. Maybe fan insults in sports itself isn't that big a deal, but clearly, racism in the labor market and having people treated differently is a big problem. And here you get a very clear handle on an aspect of it. And once you show it's a problem there, it's very likely that it shows up in arguably substantively much more important settings where it's really hard to study.

In the Netherlands for a long time, they had a limit on the number of students who could go to medical school. And it wasn't decided by the medical schools themselves; they couldn't choose whom to admit. It was partly based on a lottery. At some point, someone used that to figure out how much access to medical school is actually worth. So essentially, you have two people who are both qualified to go to medical school; one gets lucky in the lottery; one doesn't. And it turns out you're giving the person who wins the lottery basically a lot of money. Obviously, in many professions we can't just randomly assign people to different types of jobs. But here you get a handle on the value of rationing that type of education.

Card: I think that's really important. You know, we're supposed to be social scientists who are trying to see what people are doing and the problems they confront and trying to analyze them. In a way, that's different than this sort of old-fashioned Adam Smith view of the economy as a perfectly functioning tool that we're just supposed to admire. That is a difference, I think.

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US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an Applied Scientist to build the models and methods behind our life sciences AI products, with a primary focus on clinical trial operations and agentic reasoning. You will design, train, and evaluate systems that reason over complex clinical and operational logic, and ship them into products customers use directly. You will work closely with senior and principal scientists on well-scoped research problems, own your results end to end, and see your work reach production. This role combines expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will work on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step operational workflows? - How do you evaluate agent reliability and faithfulness rigorously enough to trust in high-stakes clinical settings? - How do you develop model customization methods (fine-tuning, retrieval augmentation, domain adaptation) that let customers get strong results from foundation models on their own data? You will focus on clinical trial operations (agentic automation, structured reasoning, evaluation, domain adaptation), with opportunities to contribute across drug discovery (protein engineering, antibody design) as the portfolio grows. You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that scientists use daily. Key job responsibilities - Design, train, fine-tune, and evaluate LLM-based agentic systems that reason over clinical protocols, regulatory standards, and operational workflows - Build rigorous evaluation harnesses and benchmarks to measure agent reliability, faithfulness, and failure modes in high-stakes domains - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that help customers get better outputs on their own data with less effort - Contribute to graph-based and causal modeling approaches for clinical trial operations - Partner with Life Sciences domain experts, product, and engineering to translate scientific challenges into shipped capabilities - Own experiments end to end: problem framing, implementation, evaluation, iteration, and hand-off to production - Publish at top-tier venues where the work supports it - Contribute to drug discovery efforts (protein engineering, antibody design) as opportunities arise A day in the life - Design and run an experiment to validate a new agentic reasoning or fine-tuning method, then ship it as a capability customers can use - Diagnose why a model is failing on a new class of inputs and implement a fix to unblock a delivery milestone - Build or extend an evaluation benchmark to measure how faithfully an agent reasons over clinical logic - Meet with domain experts to scope what the next model release needs to do - Review results with a senior scientist, sharpen the approach, and get it over the finish line - Prototype a new idea that could become the next capability in the product About the team AWS Solutions As part of the AWS solutions organization, we have a vision to provide business applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. we blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are no-brainers to buy and easy to use. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why AWS? Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture AWS values curiosity and connection. Our employee-led and company-sponsored affinity groups promote inclusion and empower our people to take pride in what makes us unique. Our inclusion events foster stronger, more collaborative teams. Our continual innovation is fueled by the bold ideas, fresh perspectives, and passionate voices our teams bring to everything we do. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve.
US, CA, Pasadena
As a Senior Quantum Applied Scientist on our Device team, you will be a technical authority and driving force in the design and measurements of novel superconducting qubits. You will lead detailed simulation and measurement efforts to explain experimental results, inform new qubit designs, and optimize device performance, working collaboratively with our design, fabrication, processor, and exploratory research teams. This is a role with significant room for innovation: you will play a key role in finding paths towards more performant devices. We are looking for a seasoned researcher with deep expertise in superconducting circuit physics plus a proven track record of bridging design, simulation, and measurement. Success in this role requires both technical depth and a genuine passion for applied, collaborative work. The ideal candidate will excel at communication across disciplines — translating detailed analyses into actionable guidance for engineering teams — and will bring the experience and judgment to identify innovations that will have the greatest impact. Key job responsibilities • Develop simulations to predict device performance, then design and measure devices that leverage the understood scalings. • Reduce the gap between simulated predictions and measurements by building more accurate models. • Communicate scientific findings across the CQC, and, when appropriate, share results externally via conference presentations and publications in scientific journals • Identify and evaluate emerging research developments that could impact design decisions About the team The Amazon Center for Quantum Computing (CQC) is a multi-disciplinary team of scientists, engineers, and technicians, on a mission to develop a fault-tolerant quantum computer.
US, CA, Pasadena
The Amazon Web Services (AWS) Center for Quantum Computing (CQC) is a multi-disciplinary team of theoretical and experimental physicists, materials scientists, and hardware and software engineers on a mission to develop a fault-tolerant quantum computer. Throughout your internship journey, you'll have access to unparalleled resources, including state-of-the-art computing infrastructure, cutting-edge research papers, and mentorship from industry luminaries. This immersive experience will not only sharpen your technical skills but also cultivate your ability to think critically, communicate effectively, and thrive in a fast-paced, innovative environment where bold ideas are celebrated. Join us at the forefront of applied science, where your contributions will shape the future of Quantum Computing and propel humanity forward. Seize this extraordinary opportunity to learn, grow, and leave an indelible mark on the world of technology. Amazon has positions available for Quantum Research Science and Applied Science Internships in San Francisco, CA; Santa Clara, CA; Pasadena, CA; and Boston, MA. We are particularly interested in candidates with expertise in any of the following areas: superconducting qubits, cavity/circuit QED, quantum optics, open quantum systems, superconductivity, electromagnetic simulations of superconducting circuits, microwave engineering, benchmarking, quantum error correction, fabrication, etc. Key job responsibilities In this role, you will work alongside global experts to develop and implement novel, scalable solutions that advance the state-of-the-art in the areas of quantum computing. You will tackle challenging, groundbreaking research problems, work with leading edge technology, focus on highly targeted customer use-cases, and launch products that solve problems for Amazon customers. The ideal candidate should possess the ability to work collaboratively with diverse groups and cross-functional teams to solve complex problems and to communicate research findings clearly. A successful candidate will be a self-starter, comfortable with ambiguity, with strong attention to detail and the ability to thrive in a fast-paced, ever-changing environment. Leverage AI-powered tools where applicable to accelerate research, experimentation, and prototyping. Critically review and validate outputs from AI tools and automated systems. About the team Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why AWS? Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture Here at AWS, it’s in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon (gender diversity) conferences, inspire us to never stop embracing our uniqueness. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve in the cloud.