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Foundation Model Development call for proposals — Winter 2024

Advancing the frontiers of foundation model development.

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About this CFP

AWS offers a broad and deep set of services for organizations to create meaningful machine learning solutions faster. Our mission is to share our learnings and ML capabilities as fully managed services, and put them into the hands of every scientist and developer.

AWS is soliciting funding proposals related to foundation model (FM) development, including enhancements for dialogue, factual questioning and answering, text generation, document summarization, image generation, and more. Proposals should be expanding the state of the art in terms of training methods, with a focus on one of the following areas: 1) to reduce incorrect or nonsensical answers, 2) to reduce the sensitivity to tweaks to the input prompt, 3) ask clarifying questions when facing ambiguous questions, 4) develop efficiency enhancements across the training and hosting FM lifecycle.

We are inviting work that both critiques and enhances the state-of-the-art in FM, including but not limited to the following topics:

  • Reinforcement learning with human feedback
  • Scaling laws and their inverse, including for model fine-tuning
  • Novel datasets and training methods
  • Distillation with enhanced reasoning
  • Foundation models in novel modalities and domains, such as biology, manufacturing, fashion, etc.
  • Bias detection and mitigation throughout the foundation model lifecycle

AWS aims to advance foundation model development by funding the creation of open-source artifacts, datasets and code that benefit the research community at large, or impactful research that uses machine learning tools. AWS will provide credits for use on EC2 instances powered by AWS Trainium chips to help researchers develop and test solutions at scale. In addition to AWS Trainium, proposed research can be conducted using AWS AI Services, AWS ML Services (Amazon SageMaker, Amazon SageMaker Ground Truth, Amazon SageMaker Neo, and Amazon Augmented AI), and Amazon Bedrock.

Timeline

  • Submission period: January 17 - March 6, 2024 (11:59PM Pacific Time)
  • Decision letters will be sent out in October 2024

Award details

Selected Principal Investigators (PIs) may receive the following:

  • $250,000 in AWS Promotional Credits, which can be used on generally available EC2 instances that are powered by AWS Trainium chips
  • AWS Trainium training resources, including AWS tutorials and hands-on sessions with Amazon scientists and engineers

Awards are structured as one-year unrestricted gifts. The budget should include a list of expected costs specified in USD, and should not include administrative overhead costs.

Your receipt and use of AWS Promotional Credits is governed by the AWS Promotional Credit Terms and Conditions, which may be updated by AWS from time to time.

Eligibility requirements

Please refer to the ARA Program rules on the Rules and Eligibility page.

Proposal requirements

PIs are encouraged to exemplify how their proposed techniques or research studies expand the body of knowledge on pretraining and evaluation methods. PIs should either include plans for open source contributions or state that they do not plan to make any open source contributions (data or code) under the proposed effort. Proposals for this CFP should be prepared according to the proposal template and are encouraged to be a maximum of 5 pages, not including Appendices.

Selection criteria

Funding decisions are based on the creativity and quality of the scientific content, and potential impact to the research community and society at large. AWS may solicit feedback on proposal title and abstracts from select AWS customers, but final award decisions will be made solely by AWS. Proposals will be evaluated based on their express interest in open-sourcing their model artifacts, datasets, and development frameworks. Although usage of Trainium is not a requirement, proposals will be evaluated on their intention to use and explore novel hardware for AI/ML, such as Trainium.

Expectations from recipients

To the extent deemed reasonable, Award recipients should acknowledge the support from ARA. Award recipients will inform ARA of publications, presentations, code and data releases, blogs/social media posts, and other speaking engagements referencing the results of the supported research or the Award. Award recipients are expected to engage with AWS throughout the duration of their award year including, but not limited to, providing reports on the status of their research or updates and feedback to ARA via surveys. Award recipients will have the opportunity to work with ARA on an informational statement about the awarded project that may be used to generate visibility for their institutions and ARA.

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You will design, build, and continuously improve the forecasting and optimization models that ensure the right compute, storage, and networking resources are available at the right time, in the right regions, at the lowest possible cost, without ever compromising the end user experience. This is a high impact individual contributor role for someone who thrives at the intersection of applied research and production systems. You will define the scientific roadmap for capacity intelligence, turning reactive provisioning into a predictive, self optimizing engine that anticipates demand before customers feel any constraint. Key job responsibilities Define and drive the scientific strategy for capacity modelling, establishing the research agenda that transforms how WorkSpaces forecasts demand, plans supply, and allocates resources across a globally distributed infrastructure. Build advanced demand forecasting models that predict workspace usage across multiple time horizons, from intraday spikes to long range growth trajectories, incorporating signals such as customer onboarding patterns, seasonal trends, regional expansion, and macroeconomic indicators. Design supply optimization frameworks that determine optimal resource placement, instance mix, and pre warming strategies, balancing availability, performance, and cost by reasoning over hardware constraints, pricing dynamics, and service level objectives. Develop causal and probabilistic models that move beyond trend extrapolation to true understanding of demand drivers, enabling the organization to distinguish organic growth from one time events, anticipate shifts in usage patterns, and quantify uncertainty in planning decisions. Architect simulation and scenario planning systems that allow business and engineering leaders to run what if analyses, stress test capacity plans against disruption scenarios, and evaluate trade offs between investment timing, risk tolerance, and customer experience. Pioneer the integration of machine learning with operations research, combining deep learning based forecasting with mathematical optimization to jointly solve the demand prediction and resource allocation problem in a way that neither discipline can achieve alone. Establish evaluation frameworks and monitoring systems that measure forecast accuracy, capacity utilization, and cost efficiency in production, creating tight feedback loops that drive continuous model improvement and build organizational trust in science driven planning. Influence the broader organization's capacity strategy by translating model outputs into actionable recommendations for leadership, identifying opportunities to extend capacity intelligence patterns to adjacent services, and mentoring scientists and engineers across the team. About the team As part of the AWS solutions organization, we have a vision to provide business applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. we blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are no-brainers to buy and easy to use. Diverse Experiences AWS values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Why AWS? Amazon Web Services (AWS) is the world’s most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that’s why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. Inclusive Team Culture AWS values curiosity and connection. Our employee-led and company-sponsored affinity groups promote inclusion and empower our people to take pride in what makes us unique. Our inclusion events foster stronger, more collaborative teams. Our continual innovation is fueled by the bold ideas, fresh perspectives, and passionate voices our teams bring to everything we do. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve.
Senior Applied Scientist, QEC SW, MQS Center for Quantum Computing
US, CA, San Francisco
The Models, Quantum, and Silicon (MQS) Center for Quantum Computing (CQC) is a multi-disciplinary team of scientists, engineers, and technicians, on a mission to develop a fault-tolerant quantum computer. We are looking to hire a Senior Applied Scientist to join our growing Software team. You’ll work closely with our partners on the control hardware development and quantum error correction theory teams to build a quantum control system capable of supporting the next generation of fault-tolerant workloads This requires someone who (1) has a strong desire to work within a team of scientists and engineers, and (2) demonstrates ownership in initiating and driving projects to completion. Inclusive Team Culture Here at Amazon, it’s in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity (CORE) and AmazeCon conferences, inspire us to never stop embracing our uniqueness. Diverse Experiences Amazon values diverse experiences. Even if you do not meet all of the qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn’t followed a traditional path, or includes alternative experiences, don’t let it stop you from applying. Mentorship & Career Growth We’re continuously raising our performance bar as we strive to become Earth’s Best Employer. That’s why you’ll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. Work/Life Balance We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why we strive for flexibility as part of our working culture. When we feel supported in the workplace and at home, there’s nothing we can’t achieve in the cloud. Export Control Requirement Due to applicable export control laws and regulations, candidates must be either a U.S. citizen or national, U.S. permanent resident (i.e., current Green Card holder), or lawfully admitted into the U.S. as a refugee or granted asylum, or be able to obtain a US export license. If you are unsure if you meet these requirements, please apply and Amazon will review your application for eligibility. Key job responsibilities - Contribute to the software/gateware runtime for our next-generation quantum control system - Build emulation tooling to enable exploring the requirements space of control systems for real-time quantum error detection and correction - Make opinionated decisions about engineering tradeoffs to inform our control hardware/software roadmap - Demonstrate thought leadership in FTQC by releasing open-source software and publishing research - Empower other scientists to actively contribute to the codebase through mentorship and documentation We are looking for candidates with strong engineering principles, a bias for action, superior problem-solving, and excellent communication skills. Working effectively within a team environment is essential. A day in the life The majority of your time will be spent on projects that extend the functional capabilities or performance of our internal control stack. This requires working backwards from the needs of our science staff in the context of our larger experimental roadmap. You will translate science and software requirements into design proposals balancing implementation complexity against time-to-delivery. Once a design proposal has been reviewed and accepted, you’ll drive implementation and coordinate with internal stakeholders to ensure a smooth roll out. Because many high-level experimental goals have cross-cutting requirements, you’ll often work closely with other engineers or scientists or on the team. About the team You will be joining the Software group within the MQS Center of Quantum Computing. Our team is comprised of scientists and software engineers who are building scalable software that enables quantum computing technologies.
Applied Scientist, Demand Tech, Amazon Ads
GB, London
In Amazon Advertising, we apply machine learning at massive scale to optimize the prediction, ranking, and bidding behind every ad — deciding, in milliseconds, which ads to show shoppers and how to value them. We're looking for an Applied Scientist to help make sure the ads shoppers see are the right ones for them. You'll work across the science of how we rank, value, and bid on ads for Amazon DSP (Amazon's Demand-Side Platform) — including how we judge whether an ad is a good fit for the page a shopper is on and for the shopper themselves. It's high-scale, low-latency, customer-facing science: your models run live in front of millions of shoppers under tight real-time constraints. The questions are genuinely open — how do you tell whether an ad is relevant to someone, how do you balance what's good for shoppers, advertisers, and Amazon, and how do you keep getting that right as shopping behavior and inventory shift underneath you? Your work will have real impact, and you'll have room to shape where we take it. A few things make this stand out: your models touch a huge share of the ads shoppers see every day, so even small improvements add up fast; you'll run modern ML live under strict latency limits, across regions and very different types of ad inventory; and the problem space is rich — from how we value and bid on ads, to keeping models stable as traffic shifts, to what makes an ad a good fit for a shopper. Key job responsibilities - Design and improve the models that decide how ads are ranked, valued, and priced — including how relevant an ad is to the page and the shopper. - Apply and extend state-of-the-art techniques across e.g. ranking, deep learning, and information retrieval. - Own problems end to end: frame them, prototype, experiment, and ship them to production. - Balance competing objectives — shopper experience, advertiser and publisher value, and Amazon's business — into models that hold up across placements and marketplaces. - Communicate your work clearly to both business and science audiences, tailoring how you share it to each. - Write and ship your own production code backed by strong engineering support — we're all builders here. - Move fast with the best tools available, including modern AI coding assistants and agents. A day in the life You might start by digging into last week's experiment results, then use an AI coding agent to get your next prototype built and ready to test in production. In the afternoon you could be sketching a new way to measure ad relevance, reading a recent paper that bears on it, and talking it through with a senior scientist on the team. You'll move between hands-on science, writing and shipping real production code, and making the calls on your own work. About the team We're a group of scientists and engineers based in Edinburgh and London, working to make Amazon's ads more performant and relevant. We sit within a larger team spread primarily across New York City and the UK, and we have a broad mandate to build and experiment. You'll work alongside senior applied scientists you can learn from, with the data and infrastructure to do the work well and room to grow — with opportunities to attend top conferences (e.g., NeurIPS, KDD, ICML) and take on more scope over time.
Principal Applied Scientist, WorkSpaces for AI Agents, Applied AI Solutions
US, WA, Seattle
We are seeking a Principal Applied Scientist to own the scientific vision across Agentic WorkSpaces. This is a foundational role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will define how we measure, improve, and guarantee the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You will help define which ones we pursue. The problems you will solve do not have established industry patterns. You will set the direction for the science of how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. Key job responsibilities - Set the long-term scientific vision: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Identify the unsolved scientific problems, chart a multi-year research roadmap, and secure buy-in from VP-level leadership. - Solve highly ambiguous, novel problems: Independently frame and deliver solutions to foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. - Own the evaluation and measurement foundation: Build the benchmarks, datasets, and metrics that quantify agent and team accuracy, cost, productivity, and safety across the portfolio and diverse enterprise workflows, and that gate what we ship. - Drive cross-organizational scientific alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio to shape how models and agent frameworks are applied, and ensure scientific decisions compose into a coherent system. - Deliver measurable business impact: Ensure research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. - Raise the scientific bar: Establish rigor in experimentation, evaluation, and reproducibility. Mentor and grow senior scientists and engineers. Set the standard for applied science quality across the organization. - Advance the state of the art: Contribute to the external technical community through publications, patents, and open-source contributions that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
Senior Manager, Applied Science
US, WA, Seattle
We are seeking a Senior Manager, Applied Science to build and lead the science organization across Agentic WorkSpaces. This is a foundational leadership role spanning the full portfolio — Personal, Applications, and Core, and the agentic surfaces (WS4Builders and WorkSpaces for Agents). You will hire, grow, and lead a team of applied scientists who define how we measure and improve the performance of AI agents and human-AI teams. A core part of the role is defining the science agenda itself — identifying which problems are most worth solving and where the highest-leverage bets lie. Directions worth exploring might include Organizational Intelligence (turning institutional knowledge into agent-consumable skills), AI Agent Experience / AiAX (agent observability and autonomous remediation), and contextual, behavioral security that adapts enforcement in real time for human and agent sessions — but these are illustrative examples, not a fixed roadmap, and many other directions are possible. You and your team will define which ones we pursue. The problems your team will solve do not have established industry patterns. You will set the scientific direction and build the team that determines how AI agents and people perceive, reason about, and act reliably within computing environments at enterprise scale. What You Will Do Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Key job responsibilities Build and lead the applied science team. Hire, develop, and retain a high-caliber team of applied scientists spanning the Agentic WorkSpaces portfolio. Set the bar for scientific talent, create the growth paths, and build the culture that makes AAWS a destination for the best agent and human-AI researchers. Own the science strategy across the portfolio. Direct the research agenda for how we measure and improve agents and human-AI teams: the benchmarks, task suites, and metrics (accuracy, cost-per-task, task completion, productivity) that turn subjective "it works" judgments into rigorous, reproducible measurement that gates what we ship. Define and drive high-leverage research directions. Work with your team to identify the problems most worth solving and shape the science agenda. Directions worth exploring might include how agents combine deterministic tool use (MCP) with visual reasoning from computer use; Organizational Intelligence and workflow learning (learning from expert recordings, voice annotations, and SOPs); and AI Agent Experience / AiAX (detecting when agents are stuck or degrading productivity and autonomously remediating) — these are illustrative starting points, and your team will weigh them against many other possibilities. Translate science into shipped product. Partner with engineering, product, and program leaders to move models, evaluation, and learning systems from prototype into a decade-old production service operating at massive scale, without compromising the reliability that customers depend on. Represent science in leadership and to customers. Be the scientific voice in org-level planning and roadmap decisions across AAWS, and engage directly with enterprise customers on how agent performance, safety, and human-AI productivity are measured and earned. Set the long-term scientific vision and team strategy: Define what best-in-class agent performance, evaluation, and learning look like across Agentic WorkSpaces — for computer-using agents and human-AI teams alike. Chart a multi-year research roadmap, and build the team and plan to deliver it. Secure buy-in from VP-level leadership. Hire and grow scientific talent: Own recruiting, calibration, development, and retention for the science team. Mentor scientists toward senior and principal scope, and raise the scientific bar across the organization. Direct research on highly ambiguous, novel problems: Guide the team through foundational challenges in agent perception, reasoning, evaluation, reliability, and human-AI collaboration — problems where neither the approach nor the success criteria are pre-defined. Drive cross-organizational alignment: Work across partner teams (AgentCore, Bedrock model teams, Identity, Security, the MCP ecosystem) and across the Applied AI Solutions product portfolio, with product and engineering leadership, to ensure scientific decisions compose into a coherent product. Deliver measurable business impact: Ensure your team's research translates to customer outcomes: higher task accuracy, lower cost-per-action, faster time-to-production, measurable productivity for human-AI teams, and the trust that lets enterprises scale agent workflows. Establish scientific rigor and operational excellence: Set the standard for experimentation, evaluation, and reproducibility, and the mechanisms that keep the science organization productive and accountable. Advance the state of the art: Enable and champion contributions to the external technical community through publications, patents, and open-source work that position AWS as the leader in the science of secure agent-computer interaction and human-AI teamwork. About the team AWS Applied AI Solutions' (AAIS) vision is every business innovating with Amazon AI teammates. Our mission is to build delightful AI solutions that improve human capabilities and business outcomes. The Agentic WorkSpaces organization within AAIS envisions a world where people, teams, and AI collaborate securely from anywhere to create unprecedented value for every organization. We build lovable products that empower every business to unlock the full potential of human-AI teamwork, driving smarter decisions, greater creativity, more value, and faster innovation with confidence. Amazon Agentic WorkSpaces (AAWS) is building the world's most lovable, secure, and trusted always-on workspace where AI agents and humans work as partners behind enterprise-grade security. Our portfolio spans persistent desktops (Personal), application streaming (Applications), and Core, and is evolving into the governed operating environment for the hybrid workforce: humans get AI-native desktops for their role, and agents get governed desktops scoped to their task, with administrators managing both as one. This surface includes WS4Builders (an AI-native environment for builders) and WorkSpaces for Agents (W4A) — enabling AI agents to work the way humans do, with access to real applications, real interfaces, and real computing environments. Enterprises want to use AI agents for critical business workloads that touch legacy desktop applications and mainframes, yet 75% of organizations run legacy applications that lack modern APIs, and 90% of corporate data remains locked in systems never designed for agents. Agentic WorkSpaces solves this: it gives enterprises a secure, governed environment where agents and humans operate both legacy and modern applications directly, just as an employee would, without costly migrations.
Principal Applied Scientist - AI for Life Sciences, AWS Applied AI Solutions - Life Sciences
US, WA, Seattle
As part of the AWS Applied AI Solutions organization, we have a vision to provide end user applications, leveraging Amazon's unique experience and expertise, that are used by millions of companies worldwide to manage day-to-day operations. We will accomplish this by accelerating our customers' businesses through delivery of intuitive and differentiated technology solutions that solve enduring business challenges. We blend vision with curiosity and Amazon's real-world experience to build opinionated, turnkey solutions. Where customers prefer to buy over build, we become their trusted partner with solutions that are easy to adopt and easy to use. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions, where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients, powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models, large language models, and agentic reasoning systems to life sciences problems, then put them into the hands of pharma, biotech, and diagnostics customers as applications and managed services they can fine-tune, tailor, and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological, regulatory, and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In drug design, our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. In clinical trials, we're building AI that automates and optimizes regulatory and clinical development workflows. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor, encourage publication, and support conference participation. If you want to do research that ships, this is the team. The Role We are seeking an exceptional Principal Applied Scientist to set the scientific direction for our life sciences AI portfolio. You will be the scientific leader who defines research agendas, architects novel approaches, and delivers models and methods that give our customers capabilities that did not previously exist. This is a rare role that combines deep expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will innovate on how large language models reason, plan, and act in complex scientific domains, while applying domain knowledge in biology to ensure models produce scientifically valid outputs. The problems span multiple fronts: - How do you build LLM-based agentic systems that correctly reason over clinical protocols, regulatory standards, and complex multi-step scientific workflows? - How do you develop model customization and training methods that let customers get state-of-the-art results from foundation models? - How do you adapt and extend protein and antibody models so customers can fine-tune on proprietary sequence data and get therapeutically relevant outputs? You will work across drug discovery (protein engineering, antibody design) and clinical trial operations (agentic automation, structured reasoning, domain adaptation). You will own end-to-end scientific solutions from research through production, and your work will directly shape the tools that thousands of scientists use daily. Key job responsibilities - Set the scientific vision and research agenda for LLM reasoning, agentic AI, and biological model customization across the portfolio - Innovate on LLM reasoning, planning, and agentic approaches for complex scientific and regulatory workflows - Develop model customization methods (fine-tuning, RLHF, retrieval augmentation, domain adaptation) that enable customers to train better models on their own data with less effort - Advance methods to adapt and extend biological foundation models for customer-specific therapeutic applications - Solve open research problems in faithful reasoning, multi-step planning, and tool use in high-stakes scientific domains - Partner with Life Sciences domain experts and customers to understand their hardest scientific challenges and translate those into tractable research problems - Publish at top-tier venues and build the team's external scientific reputation - Mentor applied scientists across the team while maintaining significant personal research contribution - Collaborate with product and engineering to ensure research translates into shipped products that serve customers at scale - Influence multi-year research roadmaps through deep scientific expertise and customer understanding A day in the life - Push a new reasoning approach into production that measurably improves outputs for a pharma customer's workflow - Design and run experiments to validate a novel fine-tuning method, then ship it as a capability customers can use immediately - Unblock a delivery milestone by diagnosing why a model is failing on a new class of inputs and implementing a fix - Meet with a customer's scientific team to scope what the next model release needs to do for them - Review a teammate's experimental results, sharpen the approach, and help get it over the finish line - Publish results from shipped work at a top venue, closing the loop between research and impact - Prototype a new idea that could become the next major capability in the product
Applied Scientist II, Amazon Shipping
IN, HR, Gurugram
Work on ML teams building large-scale forecasting and optimization systems that power Amazon’s global transportation network and directly impact customer experience and cost. As an Applied Scientist II, you will set scientific direction, mentor applied scientists, and partner with engineering and product leaders to deliver production-grade ML solutions at massive scale. Key job responsibilities 1. Lead and grow a high-performing team of Applied Scientists, providing technical guidance, mentorship, and career development. 2. Define and own the scientific vision and roadmap for ML solutions powering large-scale transportation planning and execution. 3. Guide model and system design across a range of techniques, including tree-based models, deep learning (LSTMs, transformers), LLMs, and reinforcement learning. 4. Ensure models are production-ready, scalable, and robust through close partnership with stakeholders. Partner with Product, Operations, and Engineering leaders to enable proactive decision-making and corrective actions. 5. Own end-to-end business metrics, directly influencing customer experience, cost optimization, and network reliability. 6. Help contribute to the broader ML community through publications, conference submissions, and internal knowledge sharing. A day in the life Your day includes reviewing model performance and business metrics, guiding technical design and experimentation, mentoring scientists, and driving roadmap execution. You’ll balance near-term delivery with long-term innovation while ensuring solutions are robust, interpretable, and scalable. Ultimately, your work helps improve delivery reliability, reduce costs, and enhance the customer experience at massive scale.
Applied Scientist, Perfect Order Experience (POE)
US, WA, Seattle
We’re pioneering frontier science solutions to detect and treat product quality issues and enhance post-order experience in Amazon. Our goal is to enhance support for our diverse seller community and foster improved outcomes for both sellers and consumers for broader Amazon ecosystem. We are looking for passionate innovators who are excited about technology, driven by customer experience, and eager to make a lasting impact on the industry. In this role, you'll collaborate with top-tier scientists, engineers, and technical program managers (TPMs) to drive innovation in GenAI foundation models, adapt Large language model to our domain, develop efficient tabular foundation model, innovate on behavior foundation model. You will lead the effort to leverage Amazon's large-scale computing resources to accelerate advances in GenAI and frontier ML solutions. If you’re enthusiastic about joining a dynamic and motivated team, this is your chance to be part of an exciting journey. Apply now and help us shape the future of seller support at Amazon! Key job responsibilities 1. Develop domain-specific foundation models. 2. Apply the domain-specific foundation model to product risk detection, seller interactions capturing, future seller behaviors prediction, and seller responses simulation across varied conditions. 3. Work with business and engineers to develop and deploy the solutions.
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