George Michailidis paper abstract.jpg
Sequential change-point detection in high-dimensional Gaussian graphic models”, published by Hossein Keshavarz, a senior data scientist at relationalAI; George Michailidis; and Yves Atchadé, a professor of statistics at Boston University, touches on the theme of anomaly detection.

George Michailidis: How to identify important changes in online networks

Amazon Scholar discusses the evolution of anomaly detection research.

As the director of the University of Florida Informatics Institute, George Michailidis, who is also an Amazon Scholar on the Supply Chain Optimization Technologies (SCOT) team, leads a diverse community of data scientists with training in engineering, statistics, applied math, and other sciences. He notes that assortment of backgrounds is important in data science.

George Michailidis is the director of the University of Florida Informatics Institute, and an Amazon Scholar on the Supply Chain Optimization Technologies team.
George Michailidis is the director of the University of Florida Informatics Institute, and an Amazon Scholar on the Supply Chain Optimization Technologies team.

“In addition to statistics, there are a number of other disciplines that data scientists need to be aware of, such as programming, algorithms, optimization, and of course, some subject matter expertise because you don't do data science in a vacuum,” he says.

Michailidis was trained in applied mathematics and statistics, with a PhD thesis focused on optimization problems and its applications to statistical problems. His postdoc was in operations research, which introduced him to a different class of problems. “Some of them come about in Amazon’s supply chain, for example, such as problems of how to schedule the jobs on the machine, or how to route the traffic in the network, and so forth.”

For about 17 years, Michailidis was a faculty member at the University of Michigan in statistics with a joint appointment in electrical engineering. “I combined my statistical training with my interest in engineering types of problems.”

Data integration

Since then, his research agenda at the University of Florida has had strong theoretical components, but he remains very interested in practical applications. One of his current interests is data integration, and its many potential uses. For example, when it comes to the study of diseases, there is a wealth of molecular-level data from patients’ samples. At the same time, there is information on the patient's clinical records and demographics.

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“How do you create models to try to identify key drivers, for example, for disease progression by combining all these different data sources,” is one of the questions that motivates Michailidis’ work. With these models, he tries to provide insights both for prognostic or diagnostic purposes, but also for the understanding of the biological mechanisms that lead to that disease.

Another large component of Michailidis’ research relates to a problem known as anomaly detection. “This is an old problem that has been going on for more than 60 years,” he says. To a large extent, it originated in manufacturing, where people were interested in finding defects in the manufacturing process and fixing them. As the technology evolved, similar questions have been arising in many other fields.

This is broadly the theme of a paper published by Michailidis and his colleagues Hossein Keshavarz, a senior data scientist at relationalAI, and Yves Atchadé, a professor of statistics at Boston University, entitled “Sequential change-point detection in high-dimensional Gaussian graphic models.”

Michailidis notes that, as manufacturing processes became more complex, it became necessary to monitor many more metrics.

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“A typical example of this complexity is semiconductor manufacturing, where you have to monitor hundreds of little things,” he says.

In more modern applications, the next step is to monitor networks.

“You’re not only monitoring a lot of things. Now these things are interconnected and you're trying to understand how this network, as an object, changes its structure at some point in time,” Michailidis explains. “And you're doing that in an online fashion because this process keeps going. You keep observing the network and you're trying to identify changes as quickly as possible.”

In addition to developing a technique to detect changes, researchers also must establish that their technique is sensitive enough for certain types of changes and determine whether it detects them quickly enough. This is the challenge, in the online realm, that Michailidis and his colleagues attempt to address in their paper. The paper introduces “introduces a novel scalable online algorithm for detecting an unknown number of abrupt changes”.

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In the paper, the authors present an application on stock market data, where the network is made of movements of stocks. “We showed how the network changes, for example, during the great financial crisis of 2008, and how the stock market got affected by the European debt crisis in 2012 and so forth.” Michailidis notes that these techniques are especially suited for problems where there are dependencies between observable elements without knowledge of the nature of those dependencies.

“With stocks, whether they are moving together or in different directions, these movements —or lack of movement — is what gives rise to the network structure. And that’s what we are capturing with these graphical models,” he says.

Within the SCOT organization, Michailidis says he has the opportunity to tackle challenging problems at an unprecedented scale. “The problems are much more complex because they're not as clear cut as they are in academia.” In this interview, he discusses his research on anomaly detection and its potential applications.

  1. Q. 

    Your paper mentions high dimensional piecewise sparse graphical models. What does that entail and what are some applications?

    A. 

    The graphical model is a particular statistical model that tries to capture statistical dependencies between the things that are measured on the nodes. In the stock market example, you're looking at the rate of return of a stock. This is the measurement that you have on every node over time and you're trying to understand, for example, whether the return of one technology stock is correlated with the return of some other technology stock. So that's what the graphical model is trying to capture — the statistical dependencies.

    The next step is what we mean by high dimensional. Essentially, it means that the number of nodes, or variables, in your network becomes very large compared to how many observations you have. You may have a short observation period, but with a high number of nodes. What we call high-dimensional statistics became a big field of study 15 to 20 years ago, with a lot of applications. The reason is that, in more classical statistics, we always made the assumption that the sample size in our observations is much larger than the number of variables. In the high-dimensional regime, the relationship flips and you have many more variables than observations and that poses a whole bunch of technical challenges, to the point where you can’t even solve the problem.

    So, you need some additional assumptions, and that's where another important term comes in: sparse. This means that this network doesn't have too many connections. If it was very well connected, then we would not be able to solve the problem for technical reasons, because you would not have enough data. So, you make the assumption that these networks are not too connected to compensate for how much data you have.

    And the last term we need to understand is piecewise. By piecewise, we mean that, for this period, the network structure stays the same, and then changes abruptly to some other structure. It's not a gradual change — although this may be happening in reality. It heavily depends on the underlying application. It may either be a simplifying assumption in order to do the analysis or, in many cases, that's exactly what happens.

    In the neuroscience example, if the subject sits in the scanner without moving, and then you tell them — “raise your hand or read this sentence” — there is an abrupt change because there is a new task after a resting state. This is also possible in the stock market, where new information may create these abrupt changes.

    In many applications, there is really an abrupt change and this is the proper setting to use. In some other cases, changes may be a little bit more gradual. But we can still look at them as abrupt changes because it becomes a good working hypothesis and simplifies things. A lot of these techniques that people develop are good working models, and not exactly what's going on, that's fairly standard in a lot of scientific fields. And that explains the high dimensional piecewise sparse graphical model. That's where all the pieces come together.

  2. Q. 

    Why is it important to be able to detect these abrupt changes in an online setting?

    A. 

    Because you keep collecting the data, and you would like to identify these changes as things evolve. You could solve the same problem, with the same high dimensional sparse piecewise graphical model, in an offline manner. In that case, the difference is that you have already collected these data and would like to explore them in a retrospective manner to see if you can find these types of changes. That's also a problem of interest.

    The reason that in this article we focus on online detection is that we have already done work on the offline version, so it was natural to start exploring what is different in an online setting. And it's much, much more challenging, because you don't know the future and you keep getting new information, and you're trying to detect these changes quickly. Online problems in machine learning and other areas are more challenging than offline problems, as a general rule. So, this is for me a natural evolution, since I’ve already used these sparse graphical models in an offline setting.

  3. Q. 

    What does the paper demonstrate and how is it applicable to Amazon?

    A. 

    The paper does demonstrate that it is possible to detect these changes online, so it’s a positive message. And it also shows a caveat. If, for example, the changes in this connectivity pattern were concentrated on only one node, then we could not detect them with the current technology. Because that's a very localized change, it only involves a very tiny part of the network. And our technique would only be able to detect them by waiting for a very long time. From an applications perspective, that makes it uninteresting. That tells you the limitations, which are important in some settings. We have done most of the work, but we found out that we were missing something. So, we need to go and develop a little bit more.

    The results could be applicable to Amazon because these graphical models come up a lot. So far, we have used techniques where we haven't taken the connections into account, we have just looked simply at what is going on in the time series, let's say, of a single node and whether that changes. Obviously, given the fact that Amazon operates in a highly volatile environment, changes are important. In the longer term, given the fact that the team has done work with graphical models, it may be interesting to utilize some of these techniques. The potential is there.

    In general, anomaly detection work to date across many disciplines (statistics, signal processing, machine learning, econometrics) has largely focused on parametric models, where with some effort the theoretical properties of anomaly detection procedures can be elucidated analytically and then validated through simulations. The analytical work provides deeper insights into the performance of these anomaly detection procedures and their limitations, and when they do not perform well. With all the advances in deep learning models, they become prime tools to use in anomaly detection problems.

    However, the challenge then becomes, to understand the performance limits of such models, beyond relying on numerical work. Such advances may take some time, but once the community makes progress, much more powerful procedures will be available to the practitioners.

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We are looking for a talented, organized, and customer-focused applied researcher to join our Pricing Optimization science group, with a charter to measure, refine, and launch customer-obsessed improvements to our algorithmic pricing and promotion models across all products listed on Amazon. This role requires an individual with exceptional machine learning modeling and architecture expertise — particularly in deep learning, neural networks, and transformer-based architectures applied to price prediction and forecasting problems. Equally important is deep expertise in causal machine learning — including causal inference, treatment-effect estimation, and experimentation methods (e.g., uplift modeling, double/debiased machine learning, instrumental variables, and A/B and quasi-experimental design) — to isolate the true impact of pricing and promotion decisions on customer behavior and business outcomes. The ideal candidate brings a strong foundation in applied statistics and probabilistic modeling, excellent cross-functional collaboration skills, business acumen, and an entrepreneurial spirit. We are looking for an experienced innovator who is a self-starter, comfortable with ambiguity, demonstrates strong attention to detail, and has the ability to work in a fast-paced and ever-changing environment. Key job responsibilities See the big picture. Understand and influence the long-term vision for Amazon's science-based competitive, perception-preserving pricing techniques. Develop and advance price prediction models leveraging deep learning frameworks, transformer architectures, and advanced statistical methods to drive pricing accuracy at scale. Build strong collaborations. Partner with product, engineering, and science teams within Pricing & Promotions to deploy machine learning price estimation and error correction solutions at Amazon scale. Design and implement neural network-based architectures — including sequence models and transformers — for large-scale price prediction and optimization. Stay informed. Establish mechanisms to stay up to date on the latest scientific advancements in deep learning, transformer architectures, applied statistics, neural network design, probabilistic forecasting, and multi-objective optimization techniques. Identify opportunities to apply them to relevant Pricing & Promotions business problems. Keep innovating for our customers. Foster an environment that promotes rapid experimentation, continuous learning, and incremental value delivery. Leverage statistical rigor and modern deep learning approaches to validate hypotheses and drive measurable pricing improvements. Successfully execute & deliver. Apply your exceptional technical machine learning expertise — including deep neural networks, attention-based models, and applied statistical analysis — to incrementally move the needle on some of our hardest pricing problems. A day in the life We are hiring a Sr. Applied Scientist to drive our pricing optimization initiatives. We drive cross-domain and cross-system improvements through: * shape and extend our RL optimization platform - a pricing centric tool that automates the optimization of various system parameters and price inputs. * Error detection and price quality guardrails at scale. * Identifying opportunities to optimally price across systems and contexts (marketplaces, request types, event periods) Price is a highly relevant input into Stores architectures; this role creates the opportunity to drive extremely large impact (measured in Bs not Ms), but demands careful thought and clear communication. About the team The Pricing Optimization science group builds and refines Amazon's algorithmic pricing and promotion models at scale. Our team combines expertise in deep learning, transformer architectures, applied statistics, and probabilistic forecasting to develop price prediction systems that directly impact the customer experience. The team also brings hands-on experience with causal modeling and inference — including uplift modeling and treatment effect estimation — to rigorously measure the impact of pricing decisions on customer behavior and business outcomes. We partner closely with product, engineering, and business teams to take solutions from research through production deployment.
US, WA, Seattle
Prime Video is a first-stop entertainment destination offering customers a vast collection of premium programming in one app available across thousands of devices. Prime members can customize their viewing experience and find their favorite movies, series, documentaries, and live sports – including Amazon MGM Studios-produced series and movies; licensed fan favorites; and programming from Prime Video subscriptions such as Apple TV+, HBO Max, Peacock, Crunchyroll and MGM+. All customers, regardless of whether they have a Prime membership or not, can rent or buy titles via the Prime Video Store, and can enjoy even more content for free with ads. Are you interested in shaping the future of entertainment? Prime Video's technology teams are creating best-in-class digital video experience. As a Prime Video team member, you’ll have end-to-end ownership of the product, user experience, design, and technology required to deliver state-of-the-art experiences for our customers. You’ll get to work on projects that are fast-paced, challenging, and varied. You’ll also be able to experiment with new possibilities, take risks, and collaborate with remarkable people. We’ll look for you to bring your diverse perspectives, ideas, and skill-sets to make Prime Video even better for our customers. With global opportunities for talented technologists, you can decide where a career Prime Video Tech takes you! We are looking for passionate, hard-working, and talented individuals to help us push the envelope of content localization. We are seeking scientists with experience in audio processing, speech/voice AI and machine learning. We work on a broad array of research areas and applications, including but not limited to multimodal machine translation, speech synthesis, speech analysis, and asset quality assessment. Candidates should be prepared to help drive innovation in one or more areas of machine learning, audio processing, and natural language understanding. If you have experience with speech synthesis and foundational models, then that's a huge plus! Key job responsibilities As an Applied Scientist, you should be a strong communicator, able to describe scientifically rigorous work to business stakeholders of varying levels of technical sophistication. You will closely partner with the solution development teams, and should be intensely curious about how the research is moving the needle for business. Strong inter-personal and mentoring skills to develop applied science talent in the team is another important requirement. - Lead research and development of speech and audio generation technology and end-to-end speech-to-speech architecture - Develop audio processing solutions for production environments, including source separation, enhancement, and mixing - Define the research roadmap for your area, identify high-impact problems, and communicate technical direction to senior leadership - Publish research, contribute to the broader scientific community, and bring external advances into production systems A day in the life You might start your morning reviewing experimental results and refining a model architecture before syncing with your engineering partners on integration plans. After lunch, you could be whiteboarding a new approach to a problem your team recently identified, then writing up findings for an internal science review. You will regularly present your work to peers and stakeholders, participate in code and design reviews, and explore emerging research that could unlock new possibilities for your team. About the team Our team is driven by a shared commitment to applying science in ways that create meaningful impact for customers. We value rigorous research, collaborative problem-solving, and a willingness to experiment with new ideas. You will work alongside talented scientists and engineers in an inclusive environment where your contributions shape the direction of our work. We are focused on building solutions that matter at scale, and we are looking for teammates who are energized by that challenge.
US, NY, New York
We are seeking an Applied Scientist to lead the development of evaluation frameworks and data collection protocols for robotic capabilities. In this role, you will focus on designing how we measure, stress-test, and improve robot behavior across a wide range of real-world tasks. Your work will play a critical role in shaping how policies are validated and how high-quality datasets are generated to accelerate system performance. You will operate at the intersection of robotics, machine learning, and human-in-the-loop systems, building the infrastructure and methodologies that connect teleoperation, evaluation, and learning. This includes developing evaluation policies, defining task structures, and contributing to operator-facing interfaces that enable scalable and reliable data collection. The ideal candidate is highly experimental, systems-oriented, and comfortable working across software, robotics, and data pipelines, with a strong focus on turning ambiguous capability goals into measurable and actionable evaluation systems. Key job responsibilities - Design and implement evaluation frameworks to measure robot capabilities across structured tasks, edge cases, and real-world scenarios - Develop task definitions, success criteria, and benchmarking methodologies that enable consistent and reproducible evaluation of policies - Create and refine data collection protocols that generate high-quality, task-relevant datasets aligned with model development needs - Build and iterate on teleoperation workflows and operator interfaces to support efficient, reliable, and scalable data collection - Analyze evaluation results and collected data to identify performance gaps, failure modes, and opportunities for targeted data collection - Collaborate with engineering teams to integrate evaluation tooling, logging systems, and data pipelines into the broader robotics stack - Stay current with advances in robotics, evaluation methodologies, and human-in-the-loop learning to continuously improve internal approaches - Lead technical projects from conception through production deployment - Mentor junior scientists and engineers About the team Fauna Robotics, an Amazon company, is building capable, safe, and genuinely delightful robots for everyday life. Our goal is simple: make robots people actually want to live and interact with in everyday human spaces. We believe that future won’t arrive until building for robotics becomes far more accessible. Today, too much effort is spent reinventing the fundamentals. We’re changing that by developing tightly integrated hardware and software systems that make it faster, safer, and more intuitive to create real-world robotic products. Our work spans the full stack: mechanical design, control systems, dynamic modeling, and intelligent software. The focus is not just functionality, but experience. We’re building robots that feel responsive, expressive, and genuinely useful. At Fauna, you’ll work at the frontier of this space, helping define how robots move, manipulate, and interact with people in natural environments. It’s an opportunity to solve hard problems across hardware and software with a team focused on making robotics accessible and joyful to build. If you care about making robotics real for everyone and building systems that are as delightful as they are capable, we’re interested in hearing from you.